DegronMD

Uniprot ID: A4UGR9

Source protein: Xin actin-binding repeat-containing protein 2

Source gene: XIRP2

Class: DEG_SPOP_SBC_1

Location: 231:235

E3 ligase: SPOP

DEGRON score: 0.8956

ASA_SCORE: 79.96

COIL: 0.7546

CONS_SCORE: 0.3998

DSS_SCORE: 0.4222

HELIX: 0.0572

FCONS_SCORE: 1.0234

RIG_SCORE: 0.6735

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M242I	TCGA-14-0866	GBM	TCGA	VVSTS	DEG_SPOP_SBC_1	0.1389
p.M242I	DO11878	GBM	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1389
p.M242I	DO229177	LMS	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1389
p.S239Y	TCGA-85-6561	LUSC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.2222
p.S239Y	TCGA-GE-A2C6	THCA	TCGA	VVSTS	DEG_SPOP_SBC_1	0.2222
p.S239Y	DO26518	LUSC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.2222
p.S239Y	DO40334	THCA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.2222
p.A224V	TCGA-AP-A1DV	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.1389
p.A224V	DO32908	PACA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1389
p.A224V	DO43186	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1389
p.F238I	TCGA-CN-4731	HNSC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.25
p.F238I	DO15886	HNSC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.25
p.E221K	TCGA-EY-A215	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.0556
p.E221K	DO42665	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.0556
p.S231F	TCGA-FI-A2D0	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.7982
p.S231F	DO43891	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.7982
p.R222Q	TCGA-KK-A59V	PRAD	TCGA	VVSTS	DEG_SPOP_SBC_1	0.0833
p.R222Q	DO234242	ESAD	ICGC	VVSTS	DEG_SPOP_SBC_1	0.0833
p.R222Q	DO51346	PRAD	ICGC	VVSTS	DEG_SPOP_SBC_1	0.0833
p.S239C	TCGA-XF-AAMG	BLCA	TCGA	VVSTS	DEG_SPOP_SBC_1	0.2222
p.S239C	DO219049	BLCA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.2222
p.C235F	DO228936	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.7108
p.R222L	DO228978	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.0833
p.R225M	DO229035	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1667
p.R225M	DO224610	LUSC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1667
p.R236C	DO231690	LINC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.3056
p.R236C	DO227677	SKCA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.3056
p.E245K	DO45119	LIRI	ICGC	VVSTS	DEG_SPOP_SBC_1	0.0556
p.A224E	DO228343	MALY	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1389
p.S231A	DO232761	PBCA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.7588
p.A228T	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	VVSTS	DEG_SPOP_SBC_1	0.25
p.A228T	RF-48	stomach	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.25
p.G233S	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VVSTS	DEG_SPOP_SBC_1	0.6993
p.G233S	H513	pleura	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.6993
p.R236H	SIDM01480	Ovarian Carcinoma	GDSC	VVSTS	DEG_SPOP_SBC_1	0.3056
p.P239L	NCI-H1105	lung	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.2222
p.G245D	COLO-792	skin	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.0556
p.G245D	NCI-H446	lung	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.0556
p.D236V	NB13	autonomic_ganglia	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.3056
p.Y227H	UACC-62	skin	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.3333
p.F232V	HCC2998	large_intestine	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.7068
p.P234T	T-24	urinary_tract	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.7031
p.P230S	HCC2998	large_intestine	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.3056
p.P234Q	NCI-H2009	lung	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.7035
p.L235P	SNU-81	large_intestine	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	231:235	VVSTS	SPOP	0.8956	More...
O95235	Kinesin-like protein KIF20A	DEG_SPOP_SBC_1	45:49	VVSTS	SPOP	0.9985	More...
O95600	Krueppel-like factor 8	DEG_SPOP_SBC_1	121:125	VVSTS	SPOP	0.8645	More...
P23469	Receptor-type tyrosine-protein phosphatase epsilon	DEG_SPOP_SBC_1	78:82	VVSTS	SPOP	0.6754	More...
P51795	H	DEG_SPOP_SBC_1	724:728	VVSTS	SPOP	0.9829	More...
Q13422	DNA-binding protein Ikaros	DEG_SPOP_SBC_1	451:455	VVSTS	SPOP	0.7186	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1171:1175	VVSTS	SPOP	0.7463	More...
Q9H7D0	Dedicator of cytokinesis protein 5	DEG_SPOP_SBC_1	1679:1683	VVSTS	SPOP	0.9974	More...
O15016	Tripartite motif-containing protein 66	DEG_SPOP_SBC_1	816:820	VVSTS	SPOP	0.6338	More...
Q96BU1	S100P-binding protein	DEG_SPOP_SBC_1	270:274	VVSTS	SPOP	0.9689	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVSTS

Degron related mutations and impact score

Drug responses associated with XIRP2 mutations

All proteins holding degron of VVSTS