DegronMD

Uniprot ID: P23469

Source protein: Receptor-type tyrosine-protein phosphatase epsilon

Source gene: PTPRE

Class: DEG_SPOP_SBC_1

Location: 78:82

E3 ligase: SPOP

DEGRON score: 0.6754

ASA_SCORE: 85.06

COIL: 0.8642

CONS_SCORE: 0.6667

DSS_SCORE: 0.2706

HELIX: 0.093

FCONS_SCORE: 0.9779

RIG_SCORE: 0.777

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R70S	TCGA-50-5930	LUAD	TCGA	VVSTS	DEG_SPOP_SBC_1	0.1111
p.R70S	DO25189	LUAD	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1111
p.R75M	TCGA-55-7907	LUAD	TCGA	VVSTS	DEG_SPOP_SBC_1	0.25
p.R75M	DO25396	LUAD	ICGC	VVSTS	DEG_SPOP_SBC_1	0.25
p.S80N	TCGA-CK-4951	COAD	TCGA	VVSTS	DEG_SPOP_SBC_1	0.818
p.S80N	DO10582	COAD	ICGC	VVSTS	DEG_SPOP_SBC_1	0.818
p.G89R	TCGA-EE-A2MR	SKCM	TCGA	VVSTS	DEG_SPOP_SBC_1	0.1389
p.G89R	DO228014	SKCA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1389
p.G89R	DO37819	SKCM	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1389
p.V78A	DO228664	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.5825
p.S80I	DO229008	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.8453
p.Q74L	DO27843	MALY	ICGC	VVSTS	DEG_SPOP_SBC_1	0.2222
p.D83N	SIDM00534	Colorectal Carcinoma	GDSC	VVSTS	DEG_SPOP_SBC_1	0.3056
p.D83N	ACH-000986	Colon/Colorectal Cancer	CCLE	VVSTS	DEG_SPOP_SBC_1	0.3056
p.D83N	HT-115	large_intestine	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.3056
p.R69K	SW684	soft_tissue	COSMIC	VVSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	231:235	VVSTS	SPOP	0.8956	More...
O95235	Kinesin-like protein KIF20A	DEG_SPOP_SBC_1	45:49	VVSTS	SPOP	0.9985	More...
O95600	Krueppel-like factor 8	DEG_SPOP_SBC_1	121:125	VVSTS	SPOP	0.8645	More...
P23469	Receptor-type tyrosine-protein phosphatase epsilon	DEG_SPOP_SBC_1	78:82	VVSTS	SPOP	0.6754	More...
P51795	H	DEG_SPOP_SBC_1	724:728	VVSTS	SPOP	0.9829	More...
Q13422	DNA-binding protein Ikaros	DEG_SPOP_SBC_1	451:455	VVSTS	SPOP	0.7186	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1171:1175	VVSTS	SPOP	0.7463	More...
Q9H7D0	Dedicator of cytokinesis protein 5	DEG_SPOP_SBC_1	1679:1683	VVSTS	SPOP	0.9974	More...
O15016	Tripartite motif-containing protein 66	DEG_SPOP_SBC_1	816:820	VVSTS	SPOP	0.6338	More...
Q96BU1	S100P-binding protein	DEG_SPOP_SBC_1	270:274	VVSTS	SPOP	0.9689	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons