DegronMD - P51795(CLCN5)

CLCN5

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R718Q	TCGA-B5-A0JR	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	724:728	Mutation rewiring degron network	0.1667
p.P738L	TCGA-BF-AAOU	SKCM	TCGA	VVSTS	DEG_SPOP_SBC_1	724:728	Mutation rewiring degron network	0.0556
p.P738L	TCGA-EO-A3AU	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	724:728	Mutation rewiring degron network	0.0556
p.P738L	DO219460	SKCM	ICGC	VVSTS	DEG_SPOP_SBC_1	724:728	Mutation rewiring degron network	0.0556
p.P738L	DO43827	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	724:728	Mutation rewiring degron network	0.0556
p.S736Y	TCGA-DF-A2KU	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	724:728	Mutation rewiring degron network	0.1111
p.S736F	TCGA-EO-A22U	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	724:728	Mutation rewiring degron network	0.1111
p.L719F	DO32477	OV	ICGC	VVSTS	DEG_SPOP_SBC_1	724:728	Mutation substituting flanking lysine	0.3056
p.K726N	DO42033	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	724:728	Mutation altering degron motif	0.6918
p.D727V	ACH-001957	Bone Cancer	CCLE	VVSTS	DEG_SPOP_SBC_1	724:728	Mutation altering degron motif	0.7785

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*NOTE: the Kaplan plots were collected from OncoLnc