DegronMD

Uniprot ID: P51795

Source protein: H

Source gene: CLCN5

Class: DEG_SPOP_SBC_1

Location: 724:728

E3 ligase: SPOP

DEGRON score: 0.9829

ASA_SCORE: 68

COIL: 0.8694

CONS_SCORE: 0.6491

DSS_SCORE: 0.2668

HELIX: 0.0376

FCONS_SCORE: 1.3453

RIG_SCORE: 0.7781

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R718Q	TCGA-B5-A0JR	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.1667
p.P738L	TCGA-BF-AAOU	SKCM	TCGA	VVSTS	DEG_SPOP_SBC_1	0.0556
p.P738L	TCGA-EO-A3AU	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.0556
p.P738L	DO219460	SKCM	ICGC	VVSTS	DEG_SPOP_SBC_1	0.0556
p.P738L	DO43827	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.0556
p.S736Y	TCGA-DF-A2KU	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.1111
p.S736F	TCGA-EO-A22U	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.1111
p.L719F	DO32477	OV	ICGC	VVSTS	DEG_SPOP_SBC_1	0.3056
p.K726N	DO42033	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.6918
p.D727V	ACH-001957	Bone Cancer	CCLE	VVSTS	DEG_SPOP_SBC_1	0.7785

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	231:235	VVSTS	SPOP	0.8956	More...
O95235	Kinesin-like protein KIF20A	DEG_SPOP_SBC_1	45:49	VVSTS	SPOP	0.9985	More...
O95600	Krueppel-like factor 8	DEG_SPOP_SBC_1	121:125	VVSTS	SPOP	0.8645	More...
P23469	Receptor-type tyrosine-protein phosphatase epsilon	DEG_SPOP_SBC_1	78:82	VVSTS	SPOP	0.6754	More...
P51795	H	DEG_SPOP_SBC_1	724:728	VVSTS	SPOP	0.9829	More...
Q13422	DNA-binding protein Ikaros	DEG_SPOP_SBC_1	451:455	VVSTS	SPOP	0.7186	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1171:1175	VVSTS	SPOP	0.7463	More...
Q9H7D0	Dedicator of cytokinesis protein 5	DEG_SPOP_SBC_1	1679:1683	VVSTS	SPOP	0.9974	More...
O15016	Tripartite motif-containing protein 66	DEG_SPOP_SBC_1	816:820	VVSTS	SPOP	0.6338	More...
Q96BU1	S100P-binding protein	DEG_SPOP_SBC_1	270:274	VVSTS	SPOP	0.9689	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons