DegronMD

Uniprot ID: O95600

Source protein: Krueppel-like factor 8

Source gene: KLF8

Class: DEG_SPOP_SBC_1

Location: 121:125

E3 ligase: SPOP

DEGRON score: 0.8645

ASA_SCORE: 89.34

COIL: 0.9194

CONS_SCORE: 0.2722

DSS_SCORE: 0.6097

HELIX: 0.0194

FCONS_SCORE: 0.837

RIG_SCORE: 0.6924

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T124K	TCGA-06-0241	GBM	TCGA	VVSTS	DEG_SPOP_SBC_1	0.7306
p.T124K	DO12460	GBM	ICGC	VVSTS	DEG_SPOP_SBC_1	0.7306
p.A133T	TCGA-A5-A1OF	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.1111
p.A133T	DO42568	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1111
p.Q118K	TCGA-CR-7390	HNSC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.25
p.Q118K	DO14302	HNSC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.25
p.K112R	TCGA-D1-A17Q	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.1944
p.K112R	DO41903	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.1944
p.T126A	TCGA-E6-A2P8	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	0.3056
p.T126A	DO40924	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	0.3056
p.L120I	TCGA-EE-A3AC	SKCM	TCGA	VVSTS	DEG_SPOP_SBC_1	0.3056
p.L120I	DO37631	SKCM	ICGC	VVSTS	DEG_SPOP_SBC_1	0.3056
p.I135M	DO222762	COCA	ICGC	VVSTS	DEG_SPOP_SBC_1	0.0556
p.M129T	DO48682	LIRI	ICGC	VVSTS	DEG_SPOP_SBC_1	0.2222
p.M129I	SIDM00973	Melanoma	GDSC	VVSTS	DEG_SPOP_SBC_1	0.2222
p.M129I	ACH-000827	Skin Cancer	CCLE	VVSTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4UGR9	Xin actin-binding repeat-containing protein 2	DEG_SPOP_SBC_1	231:235	VVSTS	SPOP	0.8956	More...
O95235	Kinesin-like protein KIF20A	DEG_SPOP_SBC_1	45:49	VVSTS	SPOP	0.9985	More...
O95600	Krueppel-like factor 8	DEG_SPOP_SBC_1	121:125	VVSTS	SPOP	0.8645	More...
P23469	Receptor-type tyrosine-protein phosphatase epsilon	DEG_SPOP_SBC_1	78:82	VVSTS	SPOP	0.6754	More...
P51795	H	DEG_SPOP_SBC_1	724:728	VVSTS	SPOP	0.9829	More...
Q13422	DNA-binding protein Ikaros	DEG_SPOP_SBC_1	451:455	VVSTS	SPOP	0.7186	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	1171:1175	VVSTS	SPOP	0.7463	More...
Q9H7D0	Dedicator of cytokinesis protein 5	DEG_SPOP_SBC_1	1679:1683	VVSTS	SPOP	0.9974	More...
O15016	Tripartite motif-containing protein 66	DEG_SPOP_SBC_1	816:820	VVSTS	SPOP	0.6338	More...
Q96BU1	S100P-binding protein	DEG_SPOP_SBC_1	270:274	VVSTS	SPOP	0.9689	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons