DegronMD - Q13422(IKZF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A399G	TCGA-21-1080	LUSC	TCGA	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.1111
p.A399G	DO26502	LUSC	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.1111
p.Q458H	TCGA-44-7662	LUAD	TCGA	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.25
p.Q458H	DO23597	LUAD	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.25
p.Q458H	ACH-001719	Ovarian Cancer	CCLE	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.25
p.D459Y	TCGA-44-7662	LUAD	TCGA	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.2222
p.D459Y	DO23597	LUAD	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.2222
p.R286C	TCGA-4R-AA8I	LIHC	TCGA	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation blocking ubiquitination signal	0.7222
p.R286C	TCGA-CA-6717	COAD	TCGA	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation blocking ubiquitination signal	0.7222
p.R286C	DO8264	COAD	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation blocking ubiquitination signal	0.7222
p.R286C	DO49657	LIHC	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation blocking ubiquitination signal	0.7222
p.E462Q	TCGA-70-6722	LUSC	TCGA	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1389
p.E462Q	DO27755	LUSC	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1389
p.R445L	TCGA-86-8073	LUAD	TCGA	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation blocking phosphorylation signal	0.6111
p.R445L	DO229015	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation blocking phosphorylation signal	0.6111
p.R445L	DO23624	LUAD	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation blocking phosphorylation signal	0.6111
p.R408H	TCGA-A1-A0SJ	BRCA	TCGA	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation altering degron motif	0.8244
p.R408H	DO2866	BRCA	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation altering degron motif	0.8244
p.S457N	TCGA-AA-3492	COAD	TCGA	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.2778
p.S457N	DO8224	COAD	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.2778
p.G443D	TCGA-AA-3672	COAD	TCGA	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1111
p.G443D	TCGA-AX-A1CE	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1111
p.G443D	DO9010	COAD	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1111
p.G443D	DO42280	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1111
p.M417I	TCGA-AJ-A2QM	UCEC	TCGA	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.2778
p.M417I	DO43690	UCEC	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.2778
p.A399P	TCGA-AQ-A04J	BRCA	TCGA	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.1111
p.A399P	DO5312	BRCA	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.1111
p.A406V	TCGA-BR-4366	STAD	TCGA	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.3056
p.A406V	DO38419	STAD	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.3056
p.R286H	TCGA-C9-A480	HNSC	TCGA	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation blocking ubiquitination signal	0.7222
p.R286H	DO44455	HNSC	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation blocking ubiquitination signal	0.7222
p.E401V	TCGA-CN-A497	HNSC	TCGA	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.1667
p.E401V	DO218992	HNSC	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.1667
p.P287L	TCGA-CX-7219	HNSC	TCGA	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation rewiring degron network	0.3056
p.P287L	DO14910	HNSC	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation rewiring degron network	0.3056
p.S457R	TCGA-D3-A5GR	SKCM	TCGA	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.2778
p.S457R	DO47436	SKCM	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.2778
p.R397H	TCGA-DS-A0VN	CESC	TCGA	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation blocking phosphorylation signal	0.5
p.R397H	DO6269	CESC	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation blocking phosphorylation signal	0.5
p.E423K	TCGA-EE-A29E	SKCM	TCGA	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.1111
p.E423K	DO23158	LINC	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.1111
p.E423K	DO220913	MELA	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.1111
p.E423K	DO37831	SKCM	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.1111
p.E423K	DMS-79	lung	COSMIC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.1111
p.G281W	TCGA-EO-A3KX	UCEC	TCGA	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation blocking ubiquitination signal	0.5833
p.G281W	DO219774	UCEC	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation blocking ubiquitination signal	0.5833
p.G443S	TCGA-F4-6703	COAD	TCGA	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1111
p.G443S	DO9908	COAD	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1111
p.S464L	TCGA-FI-A2D5	UCEC	TCGA	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0833
p.S464L	DO222439	BTCA	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0833
p.S464L	DO41331	UCEC	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0833
p.Q458K	TCGA-FS-A1ZR	SKCM	TCGA	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.25
p.Q458K	DO37651	SKCM	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.25
p.E449Q	TCGA-GU-A42P	BLCA	TCGA	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.2778
p.E449Q	DO534	BLCA	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.2778
p.G443V	TCGA-IB-7651	PAAD	TCGA	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1111
p.G443V	DO46657	PAAD	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1111
p.R445H	TCGA-RS-A6TO	HNSC	TCGA	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation blocking phosphorylation signal	0.6111
p.R445H	DO219060	HNSC	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation blocking phosphorylation signal	0.6111
p.R460W	DO221161	AML	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation blocking ubiquitination signal	0.6389
p.A313T	DO230342	COCA	ICGC	EKENE	DEG_APCC_KENBOX_2	300:304	Mutation rewiring degron network	0.0833
p.A313T	DO222874	COCA	ICGC	EKENE	DEG_APCC_KENBOX_2	300:304	Mutation rewiring degron network	0.0833
p.A313T	DO233138	GACA	ICGC	EKENE	DEG_APCC_KENBOX_2	300:304	Mutation rewiring degron network	0.0833
p.T291M	DO222765	COCA	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation altering degron motif	0.8534
p.T291M	DO233624	GACA	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation altering degron motif	0.8534
p.F463L	DO222762	COCA	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation substituting flanking lysine	0.2222
p.P300S	DO234392	ESAD	ICGC	EKENE	DEG_APCC_KENBOX_2	300:304	Mutation altering degron motif	0.6752
p.P293L	DO233259	GACA	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation altering degron motif	0.7582
p.A282S	DO228978	LICA	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation rewiring degron network	0.1667
p.R460L	DO229032	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation blocking ubiquitination signal	0.6389
p.D446Y	DO229009	LICA	ICGC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1944
p.N278K	DO45301	LIRI	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation rewiring degron network	0.0556
p.R408L	DO231036	LUSC	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation altering degron motif	0.8428
p.E423D	DO231040	LUSC	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.1111
p.V419A	DO228253	MALY	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.2222
p.G414R	DO222644	MELA	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation altering degron motif	0.7568
p.G414R	DO222843	MELA	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation altering degron motif	0.7568
p.L280R	DO229518	SKCA	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation rewiring degron network	0.1111
p.R423C	SIDM02021	Esophageal Carcinoma	GDSC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.1111
p.E465K	SIDM00524	Small Cell Lung Carcinoma	GDSC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.E465K	ACH-000703	Lung Cancer	CCLE	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.E465K	DMS-79	lung	COSMIC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.0556
p.S445P	SIDM01176	B-Lymphoblastic Leukemia	GDSC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation blocking phosphorylation signal	0.6111
p.P420L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.1944
p.P420L	ACH-000951	Lung Cancer	CCLE	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.1944
p.P420L	NCI-H2342	lung	COSMIC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.1944
p.N403S	SIDM00220	Ovarian Carcinoma	GDSC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.2222
p.N403S	ACH-000962	Ovarian Cancer	CCLE	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.2222
p.N403S	ACH-001145	Ovarian Cancer	CCLE	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.2222
p.N403S	OC-314	ovary	COSMIC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.2222
p.E443D	SIDM00077	Oral Cavity Carcinoma	GDSC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1111
p.E443D	ACH-001331	Head and Neck Cancer	CCLE	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1111
p.E443D	BICR10	upper aerodigestive tract	COSMIC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.1111
p.M311I	ACH-000779	Lung Cancer	CCLE	EKENE	DEG_APCC_KENBOX_2	300:304	Mutation rewiring degron network	0.1389
p.A448V	ACH-001719	Ovarian Cancer	CCLE	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.25
p.M293V	HEC-1	endometrium	COSMIC	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation altering degron motif	0.7208
p.S412T	CAPAN-1	pancreas	COSMIC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation altering degron motif	0.7116
p.R424Q	KM12	large intestine	COSMIC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.0833
p.D290N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation altering degron motif	0.5821
p.E401D	BICR10	upper aerodigestive tract	COSMIC	QRSGLIYLT	DEG_APCC_DBOX_1	407:415	Mutation rewiring degron network	0.1667
p.Y279S	COLO-792	skin	COSMIC	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation rewiring degron network	0.0833
p.E300D	BICR10	upper aerodigestive tract	COSMIC	EKENE	DEG_APCC_KENBOX_2	300:304	Mutation altering degron motif	0.5647
p.A291T	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation altering degron motif	0.7139
p.S457T	CAPAN-1	pancreas	COSMIC	VVSTS	DEG_SPOP_SBC_1	451:455	Mutation rewiring degron network	0.2778
p.R286Q	KM12	large intestine	COSMIC	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation blocking ubiquitination signal	0.7222
p.E282K	DMS-79	lung	COSMIC	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation rewiring degron network	0.1667
p.R290S	NCI-H2126	lung	COSMIC	LSDTPYDS	DEG_SCF_FBW7_1	288:295	Mutation altering degron motif	0.7427

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IKZF1

UniProt ID: Q13422

Entrez ID: 10320

Protein name: DNA-binding protein Ikaros (Ikaros family zinc finger protein 1) (Lymphoid transcription factor LyF-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IKZF1 in