DegronMD

Uniprot ID: Q13422

Source protein: DNA-binding protein Ikaros

Source gene: IKZF1

Class: DEG_SCF_FBW7_1

Location: 288:295

E3 ligase: FBXW7

DEGRON score: 0.9955

ASA_SCORE: 80.375

COIL: 0.7106

CONS_SCORE: 0.4704

DSS_SCORE: 0.5067

HELIX: 0.0413

FCONS_SCORE: 1.1801

RIG_SCORE: 0.6604

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R286C	TCGA-4R-AA8I	LIHC	TCGA	LSDTPYDS	DEG_SCF_FBW7_1	0.7222
p.R286C	TCGA-CA-6717	COAD	TCGA	LSDTPYDS	DEG_SCF_FBW7_1	0.7222
p.R286C	DO8264	COAD	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	0.7222
p.R286C	DO49657	LIHC	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	0.7222
p.R286H	TCGA-C9-A480	HNSC	TCGA	LSDTPYDS	DEG_SCF_FBW7_1	0.7222
p.R286H	DO44455	HNSC	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	0.7222
p.P287L	TCGA-CX-7219	HNSC	TCGA	LSDTPYDS	DEG_SCF_FBW7_1	0.3056
p.P287L	DO14910	HNSC	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	0.3056
p.G281W	TCGA-EO-A3KX	UCEC	TCGA	LSDTPYDS	DEG_SCF_FBW7_1	0.5833
p.G281W	DO219774	UCEC	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	0.5833
p.T291M	DO222765	COCA	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	0.8534
p.T291M	DO233624	GACA	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	0.8534
p.P293L	DO233259	GACA	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	0.7582
p.A282S	DO228978	LICA	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	0.1667
p.N278K	DO45301	LIRI	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	0.0556
p.L280R	DO229518	SKCA	ICGC	LSDTPYDS	DEG_SCF_FBW7_1	0.1111
p.M293V	HEC-1	endometrium	COSMIC	LSDTPYDS	DEG_SCF_FBW7_1	0.7208
p.D290N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LSDTPYDS	DEG_SCF_FBW7_1	0.5821
p.Y279S	COLO-792	skin	COSMIC	LSDTPYDS	DEG_SCF_FBW7_1	0.0833
p.A291T	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LSDTPYDS	DEG_SCF_FBW7_1	0.7139
p.R286Q	KM12	large_intestine	COSMIC	LSDTPYDS	DEG_SCF_FBW7_1	0.7222
p.E282K	DMS-79	lung	COSMIC	LSDTPYDS	DEG_SCF_FBW7_1	0.1667
p.R290S	NCI-H2126	lung	COSMIC	LSDTPYDS	DEG_SCF_FBW7_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13422	DNA-binding protein Ikaros	DEG_SCF_FBW7_1	288:295	LSDTPYDS	FBXW7	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons