DegronMD

Uniprot ID: Q13422

Source protein: DNA-binding protein Ikaros

Source gene: IKZF1

Class: DEG_APCC_DBOX_1

Location: 407:415

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9858

ASA_SCORE: 92.1222

COIL: 0.6846

CONS_SCORE: 0.5481

DSS_SCORE: 0.5352

HELIX: 0.1446

FCONS_SCORE: 1.1163

RIG_SCORE: 0.7338

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A399G	TCGA-21-1080	LUSC	TCGA	QRSGLIYLT	DEG_APCC_DBOX_1	0.1111
p.A399G	DO26502	LUSC	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	0.1111
p.R408H	TCGA-A1-A0SJ	BRCA	TCGA	QRSGLIYLT	DEG_APCC_DBOX_1	0.8244
p.R408H	DO2866	BRCA	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	0.8244
p.M417I	TCGA-AJ-A2QM	UCEC	TCGA	QRSGLIYLT	DEG_APCC_DBOX_1	0.2778
p.M417I	DO43690	UCEC	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	0.2778
p.A399P	TCGA-AQ-A04J	BRCA	TCGA	QRSGLIYLT	DEG_APCC_DBOX_1	0.1111
p.A399P	DO5312	BRCA	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	0.1111
p.A406V	TCGA-BR-4366	STAD	TCGA	QRSGLIYLT	DEG_APCC_DBOX_1	0.3056
p.A406V	DO38419	STAD	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	0.3056
p.E401V	TCGA-CN-A497	HNSC	TCGA	QRSGLIYLT	DEG_APCC_DBOX_1	0.1667
p.E401V	DO218992	HNSC	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	0.1667
p.R397H	TCGA-DS-A0VN	CESC	TCGA	QRSGLIYLT	DEG_APCC_DBOX_1	0.5
p.R397H	DO6269	CESC	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	0.5
p.E423K	TCGA-EE-A29E	SKCM	TCGA	QRSGLIYLT	DEG_APCC_DBOX_1	0.1111
p.E423K	DO23158	LINC	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	0.1111
p.E423K	DO220913	MELA	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	0.1111
p.E423K	DO37831	SKCM	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	0.1111
p.E423K	DMS-79	lung	COSMIC	QRSGLIYLT	DEG_APCC_DBOX_1	0.1111
p.R408L	DO231036	LUSC	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	0.8428
p.E423D	DO231040	LUSC	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	0.1111
p.V419A	DO228253	MALY	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	0.2222
p.G414R	DO222644	MELA	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	0.7568
p.G414R	DO222843	MELA	ICGC	QRSGLIYLT	DEG_APCC_DBOX_1	0.7568
p.R423C	SIDM02021	Esophageal Carcinoma	GDSC	QRSGLIYLT	DEG_APCC_DBOX_1	0.1111
p.P420L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	QRSGLIYLT	DEG_APCC_DBOX_1	0.1944
p.P420L	ACH-000951	Lung Cancer	CCLE	QRSGLIYLT	DEG_APCC_DBOX_1	0.1944
p.P420L	NCI-H2342	lung	COSMIC	QRSGLIYLT	DEG_APCC_DBOX_1	0.1944
p.N403S	SIDM00220	Ovarian Carcinoma	GDSC	QRSGLIYLT	DEG_APCC_DBOX_1	0.2222
p.N403S	ACH-000962	Ovarian Cancer	CCLE	QRSGLIYLT	DEG_APCC_DBOX_1	0.2222
p.N403S	ACH-001145	Ovarian Cancer	CCLE	QRSGLIYLT	DEG_APCC_DBOX_1	0.2222
p.N403S	OC-314	ovary	COSMIC	QRSGLIYLT	DEG_APCC_DBOX_1	0.2222
p.S412T	CAPAN-1	pancreas	COSMIC	QRSGLIYLT	DEG_APCC_DBOX_1	0.7116
p.R424Q	KM12	large_intestine	COSMIC	QRSGLIYLT	DEG_APCC_DBOX_1	0.0833
p.E401D	BICR10	upper_aerodigestive_tract	COSMIC	QRSGLIYLT	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRSGLIYLT

Degron related mutations and impact score

Drug responses associated with IKZF1 mutations

All proteins holding degron of QRSGLIYLT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13422	DNA-binding protein Ikaros	DEG_APCC_DBOX_1	407:415	QRSGLIYLT	APC,CDC20,FZR1	0.9858	More...