DegronMD

Uniprot ID: Q13422

Source protein: DNA-binding protein Ikaros

Source gene: IKZF1

Class: DEG_APCC_KENBOX_2

Location: 300:304

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.962

ASA_SCORE: 115.76

COIL: 0.386

CONS_SCORE: 0.3204

DSS_SCORE: 0.5084

HELIX: 0.0498

FCONS_SCORE: 0.83

RIG_SCORE: 0.7159

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A313T	DO230342	COCA	ICGC	EKENE	DEG_APCC_KENBOX_2	0.0833
p.A313T	DO222874	COCA	ICGC	EKENE	DEG_APCC_KENBOX_2	0.0833
p.A313T	DO233138	GACA	ICGC	EKENE	DEG_APCC_KENBOX_2	0.0833
p.P300S	DO234392	ESAD	ICGC	EKENE	DEG_APCC_KENBOX_2	0.6752
p.M311I	ACH-000779	Lung Cancer	CCLE	EKENE	DEG_APCC_KENBOX_2	0.1389
p.E300D	BICR10	upper_aerodigestive_tract	COSMIC	EKENE	DEG_APCC_KENBOX_2	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13422	DNA-binding protein Ikaros	DEG_APCC_KENBOX_2	300:304	EKENE	APC,CDC20,FZR1	0.962	More...
Q15468	SCL-interrupting locus protein	DEG_APCC_KENBOX_2	1242:1246	EKENE	APC,CDC20,FZR1	0.9516	More...
Q6ZMT1	SH3 and cysteine-rich domain-containing protein 2	DEG_APCC_KENBOX_2	6:10	EKENE	APC,CDC20,FZR1	0.9913	More...
Q96FF9	Sororin	DEG_APCC_KENBOX_2	87:91	EKENE	APC,CDC20,FZR1	0.9924	More...
Q9UKY1	Zinc fingers and homeoboxes protein 1	DEG_APCC_KENBOX_2	209:213	EKENE	APC,CDC20,FZR1	0.9974	More...
Q8IYW2	Cilia- and flagella-associated protein 46	DEG_APCC_KENBOX_2	1380:1384	EKENE	APC,CDC20,FZR1	0.8946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons