DegronMD

Uniprot ID: Q96FF9

Source protein: Sororin

Source gene: CDCA5

Class: DEG_APCC_KENBOX_2

Location: 87:91

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9924

ASA_SCORE: 115.22

COIL: 0.909

CONS_SCORE: 0.8002

DSS_SCORE: 0.5393

HELIX: 0.0266

FCONS_SCORE: 1.1929

RIG_SCORE: 0.6832

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P93S	DO222423	MELA	ICGC	EKENE	DEG_APCC_KENBOX_2	0.2778
p.P93S	DO37425	SKCM	ICGC	EKENE	DEG_APCC_KENBOX_2	0.2778
p.S83F	DO218856	SKCA	ICGC	EKENE	DEG_APCC_KENBOX_2	0.6667
p.R95M	DO229224	THCA	ICGC	EKENE	DEG_APCC_KENBOX_2	0.2222
p.Y89H	SIDM02026	Colorectal Carcinoma	GDSC	EKENE	DEG_APCC_KENBOX_2	0.7229
p.R101W	SIDM02013	Colorectal Carcinoma	GDSC	EKENE	DEG_APCC_KENBOX_2	0.0556
p.R101L	SIDM00927	Small Cell Lung Carcinoma	GDSC	EKENE	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13422	DNA-binding protein Ikaros	DEG_APCC_KENBOX_2	300:304	EKENE	APC,CDC20,FZR1	0.962	More...
Q15468	SCL-interrupting locus protein	DEG_APCC_KENBOX_2	1242:1246	EKENE	APC,CDC20,FZR1	0.9516	More...
Q6ZMT1	SH3 and cysteine-rich domain-containing protein 2	DEG_APCC_KENBOX_2	6:10	EKENE	APC,CDC20,FZR1	0.9913	More...
Q96FF9	Sororin	DEG_APCC_KENBOX_2	87:91	EKENE	APC,CDC20,FZR1	0.9924	More...
Q9UKY1	Zinc fingers and homeoboxes protein 1	DEG_APCC_KENBOX_2	209:213	EKENE	APC,CDC20,FZR1	0.9974	More...
Q8IYW2	Cilia- and flagella-associated protein 46	DEG_APCC_KENBOX_2	1380:1384	EKENE	APC,CDC20,FZR1	0.8946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons