DegronMD

Uniprot ID: Q8IYW2

Source protein: Cilia- and flagella-associated protein 46

Source gene: CFAP46

Class: DEG_APCC_KENBOX_2

Location: 1380:1384

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8946

ASA_SCORE: 120.52

COIL: 0.1714

CONS_SCORE: 0.3602

DSS_SCORE: 0.6158

HELIX: 0.8344

FCONS_SCORE: 1.2734

RIG_SCORE: 0.5688

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1390E	H2373	pleura	COSMIC	EKENE	DEG_APCC_KENBOX_2	0.1667
p.D1390E	EM-2	haematopoietic_and_lymphoid_tissue	COSMIC	EKENE	DEG_APCC_KENBOX_2	0.1667
p.E1374D	NCI-H1734	lung	COSMIC	EKENE	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13422	DNA-binding protein Ikaros	DEG_APCC_KENBOX_2	300:304	EKENE	APC,CDC20,FZR1	0.962	More...
Q15468	SCL-interrupting locus protein	DEG_APCC_KENBOX_2	1242:1246	EKENE	APC,CDC20,FZR1	0.9516	More...
Q6ZMT1	SH3 and cysteine-rich domain-containing protein 2	DEG_APCC_KENBOX_2	6:10	EKENE	APC,CDC20,FZR1	0.9913	More...
Q96FF9	Sororin	DEG_APCC_KENBOX_2	87:91	EKENE	APC,CDC20,FZR1	0.9924	More...
Q9UKY1	Zinc fingers and homeoboxes protein 1	DEG_APCC_KENBOX_2	209:213	EKENE	APC,CDC20,FZR1	0.9974	More...
Q8IYW2	Cilia- and flagella-associated protein 46	DEG_APCC_KENBOX_2	1380:1384	EKENE	APC,CDC20,FZR1	0.8946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons