DegronMD - Q6ZMT1(STAC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K7N	TCGA-05-4396	LUAD	TCGA	EKENE	DEG_APCC_KENBOX_2	6:10	Mutation altering degron motif	0.6918
p.K7N	DO23838	LUAD	ICGC	EKENE	DEG_APCC_KENBOX_2	6:10	Mutation altering degron motif	0.6918
p.Q377K	TCGA-33-4566	LUSC	TCGA	LKENQ	DEG_APCC_KENBOX_2	373:377	Mutation altering degron motif	0.5833
p.Q377K	DO26790	LUSC	ICGC	LKENQ	DEG_APCC_KENBOX_2	373:377	Mutation altering degron motif	0.5833
p.I378M	TCGA-CA-5254	COAD	TCGA	LKENQ	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.3056
p.I378M	DO8674	COAD	ICGC	LKENQ	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.3056
p.S78F	TCGA-DA-A95Y	SKCM	TCGA	LATPSPS	DEG_SCF_FBW7_1	88:94	Mutation blocking phosphorylation signal	0.5
p.S78F	DO223908	SKCM	ICGC	LATPSPS	DEG_SCF_FBW7_1	88:94	Mutation blocking phosphorylation signal	0.5
p.G383C	TCGA-HF-A5NB	STAD	TCGA	LKENQ	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.1667
p.G383C	DO50127	STAD	ICGC	LKENQ	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.1667
p.P20T	TCGA-IG-A4P3	ESCA	TCGA	EKENE	DEG_APCC_KENBOX_2	6:10	Mutation rewiring degron network	0.0556
p.M371I	TCGA-UY-A9PF	BLCA	TCGA	LKENQ	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.2778
p.M371I	DO219044	BLCA	ICGC	LKENQ	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.2778
p.A14V	DO10844	ESAD	ICGC	EKENE	DEG_APCC_KENBOX_2	6:10	Mutation rewiring degron network	0.2222
p.A15D	DO228948	LICA	ICGC	EKENE	DEG_APCC_KENBOX_2	6:10	Mutation rewiring degron network	0.1944
p.S372R	DO229029	LICA	ICGC	LKENQ	DEG_APCC_KENBOX_2	373:377	Mutation blocking phosphorylation signal	0.75
p.S5R	DO229022	LICA	ICGC	EKENE	DEG_APCC_KENBOX_2	6:10	Mutation rewiring degron network	0.3056
p.A104V	DO231786	LINC	ICGC	LATPSPS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.0556
p.P93L	DO220907	MELA	ICGC	LATPSPS	DEG_SCF_FBW7_1	88:94	Mutation altering degron motif	0.6471
p.V380L	DO229459	SKCA	ICGC	LKENQ	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.25
p.S78P	DO229218	THCA	ICGC	LATPSPS	DEG_SCF_FBW7_1	88:94	Mutation blocking phosphorylation signal	0.5
p.S78P	ACH-000159	Kidney Cancer	CCLE	LATPSPS	DEG_SCF_FBW7_1	88:94	Mutation blocking phosphorylation signal	0.5
p.S78P	OS-RC-2	kidney	COSMIC	LATPSPS	DEG_SCF_FBW7_1	88:94	Mutation blocking phosphorylation signal	0.5
p.S92T	DO229221	THCA	ICGC	LATPSPS	DEG_SCF_FBW7_1	88:94	Mutation altering degron motif	0.7116
p.P11T	SIDM00621	Ewing's Sarcoma	GDSC	EKENE	DEG_APCC_KENBOX_2	6:10	Mutation rewiring degron network	0.3056
p.P11T	ACH-002113	Bone Cancer	CCLE	EKENE	DEG_APCC_KENBOX_2	6:10	Mutation rewiring degron network	0.3056
p.P11T	EW-13	bone	COSMIC	EKENE	DEG_APCC_KENBOX_2	6:10	Mutation rewiring degron network	0.3056
p.S18N	SIDM00217	Colorectal Carcinoma	GDSC	EKENE	DEG_APCC_KENBOX_2	6:10	Mutation blocking phosphorylation signal	0.5556
p.S18N	ACH-000999	Colon/Colorectal Cancer	CCLE	EKENE	DEG_APCC_KENBOX_2	6:10	Mutation blocking phosphorylation signal	0.5556
p.S18N	SNU-1040	large intestine	COSMIC	EKENE	DEG_APCC_KENBOX_2	6:10	Mutation blocking phosphorylation signal	0.5556
p.P101S	SIDM01059	Melanoma	GDSC	LATPSPS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.1389
p.P101S	ACH-000915	Skin Cancer	CCLE	LATPSPS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.1389
p.P101S	IPC-298	skin	COSMIC	LATPSPS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.1389
p.V380M	SIDM01709	Melanoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.25
p.V380M	ACH-000275	Non-Cancerous	CCLE	LKENQ	DEG_APCC_KENBOX_2	373:377	Mutation rewiring degron network	0.25
p.T82A	ACH-001392	Breast Cancer	CCLE	LATPSPS	DEG_SCF_FBW7_1	88:94	Mutation rewiring degron network	0.1667

Kaplan plot for STAC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STAC2

UniProt ID: Q6ZMT1

Entrez ID: 342667

Protein name: SH3 and cysteine-rich domain-containing protein 2 (24b2/STAC2) (Src homology 3 and cysteine-rich domain-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STAC2 in