DegronMD

Uniprot ID: Q6ZMT1

Source protein: SH3 and cysteine-rich domain-containing protein 2

Source gene: STAC2

Class: DEG_SCF_FBW7_1

Location: 88:94

E3 ligase: FBXW7

DEGRON score: 0.9676

ASA_SCORE: 92.9286

COIL: 0.9751

CONS_SCORE: 0.5557

DSS_SCORE: 0.6655

HELIX: 0.0091

FCONS_SCORE: 0.9964

RIG_SCORE: 0.5467

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S78F	TCGA-DA-A95Y	SKCM	TCGA	LATPSPS	DEG_SCF_FBW7_1	0.5
p.S78F	DO223908	SKCM	ICGC	LATPSPS	DEG_SCF_FBW7_1	0.5
p.A104V	DO231786	LINC	ICGC	LATPSPS	DEG_SCF_FBW7_1	0.0556
p.P93L	DO220907	MELA	ICGC	LATPSPS	DEG_SCF_FBW7_1	0.6471
p.S78P	DO229218	THCA	ICGC	LATPSPS	DEG_SCF_FBW7_1	0.5
p.S78P	ACH-000159	Kidney Cancer	CCLE	LATPSPS	DEG_SCF_FBW7_1	0.5
p.S78P	OS-RC-2	kidney	COSMIC	LATPSPS	DEG_SCF_FBW7_1	0.5
p.S92T	DO229221	THCA	ICGC	LATPSPS	DEG_SCF_FBW7_1	0.7116
p.P101S	SIDM01059	Melanoma	GDSC	LATPSPS	DEG_SCF_FBW7_1	0.1389
p.P101S	ACH-000915	Skin Cancer	CCLE	LATPSPS	DEG_SCF_FBW7_1	0.1389
p.P101S	IPC-298	skin	COSMIC	LATPSPS	DEG_SCF_FBW7_1	0.1389
p.T82A	ACH-001392	Breast Cancer	CCLE	LATPSPS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZMT1	SH3 and cysteine-rich domain-containing protein 2	DEG_SCF_FBW7_1	88:94	LATPSPS	FBXW7	0.9676	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons