DegronMD

Uniprot ID: Q6ZMT1

Source protein: SH3 and cysteine-rich domain-containing protein 2

Source gene: STAC2

Class: DEG_APCC_KENBOX_2

Location: 373:377

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8664

ASA_SCORE: 71.32

COIL: 0.7306

CONS_SCORE: 0.5436

DSS_SCORE: 0.2851

HELIX: 0.0106

FCONS_SCORE: 0.9809

RIG_SCORE: 0.8303

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q377K	TCGA-33-4566	LUSC	TCGA	LKENQ	DEG_APCC_KENBOX_2	0.5833
p.Q377K	DO26790	LUSC	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.5833
p.I378M	TCGA-CA-5254	COAD	TCGA	LKENQ	DEG_APCC_KENBOX_2	0.3056
p.I378M	DO8674	COAD	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.3056
p.G383C	TCGA-HF-A5NB	STAD	TCGA	LKENQ	DEG_APCC_KENBOX_2	0.1667
p.G383C	DO50127	STAD	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.1667
p.M371I	TCGA-UY-A9PF	BLCA	TCGA	LKENQ	DEG_APCC_KENBOX_2	0.2778
p.M371I	DO219044	BLCA	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.2778
p.S372R	DO229029	LICA	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.75
p.V380L	DO229459	SKCA	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.25
p.V380M	SIDM01709	Melanoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	0.25
p.V380M	ACH-000275	Non-Cancerous	CCLE	LKENQ	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00577	Transcriptional activator protein Pur-alpha	DEG_APCC_KENBOX_2	159:163	LKENQ	APC,CDC20,FZR1	0.9903	More...
Q5W0Q7	SUMO-specific isopeptidase USPL1	DEG_APCC_KENBOX_2	747:751	LKENQ	APC,CDC20,FZR1	0.8582	More...
Q6ZMT1	SH3 and cysteine-rich domain-containing protein 2	DEG_APCC_KENBOX_2	373:377	LKENQ	APC,CDC20,FZR1	0.8664	More...
Q96QR8	Transcriptional activator protein Pur-beta	DEG_APCC_KENBOX_2	135:139	LKENQ	APC,CDC20,FZR1	0.735	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons