DegronMD - Q5W0Q7(USPL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T738P	TCGA-A5-A0G2	UCEC	TCGA	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.0833
p.T738P	DO41235	UCEC	ICGC	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.0833
p.A973G	TCGA-ER-A19P	SKCM	TCGA	LSPTPVST	DEG_SCF_FBW7_1	976:983	Mutation rewiring degron network	0.25
p.A973G	DO47623	SKCM	ICGC	LSPTPVST	DEG_SCF_FBW7_1	976:983	Mutation rewiring degron network	0.25
p.K753M	TCGA-NC-A5HP	LUSC	TCGA	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.2778
p.K753M	DO219199	LUSC	ICGC	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.2778
p.L976F	DO229022	LICA	ICGC	LSPTPVST	DEG_SCF_FBW7_1	976:983	Mutation altering degron motif	0.6981
p.E987K	DO45237	LIRI	ICGC	LSPTPVST	DEG_SCF_FBW7_1	976:983	Mutation rewiring degron network	0.2222
p.S739C	SIDM00319	Melanoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.1111
p.S739C	SIDM00210	Ovarian Carcinoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.1111
p.S739C	SIDM00694	Other Solid Cancers	GDSC	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.1111
p.S739C	SIDM00203	Ewing's Sarcoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.1111
p.S739C	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.1111
p.S739C	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.1111
p.S739C	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.1111
p.S739C	SIDM00785	Acute Myeloid Leukemia	GDSC	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.1111
p.S739C	SIDM01686	Chronic Myelogenous Leukemia	GDSC	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.1111
p.S739C	SIDM01664	Prostate Carcinoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.1111
p.S739C	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.1111
p.S746F	SIDM00193	Colorectal Carcinoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.3056
p.S746F	ACH-000991	Colon/Colorectal Cancer	CCLE	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.3056
p.S746F	SNU-81	large intestine	COSMIC	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.3056
p.E761Q	SK-LU-1	lung	COSMIC	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation substituting flanking lysine	0.1667
p.F755L	MFE-280	endometrium	COSMIC	LKENQ	DEG_APCC_KENBOX_2	747:751	Mutation rewiring degron network	0.2222

Kaplan plot for USPL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USPL1

UniProt ID: Q5W0Q7

Entrez ID: 10208

Protein name: SUMO-specific isopeptidase USPL1 (EC 3.4.22.-) (Ubiquitin-specific peptidase-like protein 1) (USP-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USPL1 in