DegronMD

Uniprot ID: Q5W0Q7

Source protein: SUMO-specific isopeptidase USPL1

Source gene: USPL1

Class: DEG_SCF_FBW7_1

Location: 976:983

E3 ligase: FBXW7

DEGRON score: 0.995

ASA_SCORE: 73.9875

COIL: 0.8776

CONS_SCORE: 0.5091

DSS_SCORE: 0.5359

HELIX: 0.0453

FCONS_SCORE: 1.212

RIG_SCORE: 0.7285

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A973G	TCGA-ER-A19P	SKCM	TCGA	LSPTPVST	DEG_SCF_FBW7_1	0.25
p.A973G	DO47623	SKCM	ICGC	LSPTPVST	DEG_SCF_FBW7_1	0.25
p.L976F	DO229022	LICA	ICGC	LSPTPVST	DEG_SCF_FBW7_1	0.6981
p.E987K	DO45237	LIRI	ICGC	LSPTPVST	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5W0Q7	SUMO-specific isopeptidase USPL1	DEG_SCF_FBW7_1	976:983	LSPTPVST	FBXW7	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons