DegronMD

Uniprot ID: Q5W0Q7

Source protein: SUMO-specific isopeptidase USPL1

Source gene: USPL1

Class: DEG_APCC_KENBOX_2

Location: 747:751

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8582

ASA_SCORE: 106.38

COIL: 0.6914

CONS_SCORE: 0.3967

DSS_SCORE: 0.4736

HELIX: 0.2796

FCONS_SCORE: 0.8984

RIG_SCORE: 0.7254

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T738P	TCGA-A5-A0G2	UCEC	TCGA	LKENQ	DEG_APCC_KENBOX_2	0.0833
p.T738P	DO41235	UCEC	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.0833
p.K753M	TCGA-NC-A5HP	LUSC	TCGA	LKENQ	DEG_APCC_KENBOX_2	0.2778
p.K753M	DO219199	LUSC	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.2778
p.S739C	SIDM00319	Melanoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	0.1111
p.S739C	SIDM00210	Ovarian Carcinoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	0.1111
p.S739C	SIDM00694	Other Solid Cancers	GDSC	LKENQ	DEG_APCC_KENBOX_2	0.1111
p.S739C	SIDM00203	Ewing's Sarcoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	0.1111
p.S739C	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	0.1111
p.S739C	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	0.1111
p.S739C	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	0.1111
p.S739C	SIDM00785	Acute Myeloid Leukemia	GDSC	LKENQ	DEG_APCC_KENBOX_2	0.1111
p.S739C	SIDM01686	Chronic Myelogenous Leukemia	GDSC	LKENQ	DEG_APCC_KENBOX_2	0.1111
p.S739C	SIDM01664	Prostate Carcinoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	0.1111
p.S739C	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	0.1111
p.S746F	SIDM00193	Colorectal Carcinoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	0.3056
p.S746F	ACH-000991	Colon/Colorectal Cancer	CCLE	LKENQ	DEG_APCC_KENBOX_2	0.3056
p.S746F	SNU-81	large_intestine	COSMIC	LKENQ	DEG_APCC_KENBOX_2	0.3056
p.E761Q	SK-LU-1	lung	COSMIC	LKENQ	DEG_APCC_KENBOX_2	0.1667
p.F755L	MFE-280	endometrium	COSMIC	LKENQ	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00577	Transcriptional activator protein Pur-alpha	DEG_APCC_KENBOX_2	159:163	LKENQ	APC,CDC20,FZR1	0.9903	More...
Q5W0Q7	SUMO-specific isopeptidase USPL1	DEG_APCC_KENBOX_2	747:751	LKENQ	APC,CDC20,FZR1	0.8582	More...
Q6ZMT1	SH3 and cysteine-rich domain-containing protein 2	DEG_APCC_KENBOX_2	373:377	LKENQ	APC,CDC20,FZR1	0.8664	More...
Q96QR8	Transcriptional activator protein Pur-beta	DEG_APCC_KENBOX_2	135:139	LKENQ	APC,CDC20,FZR1	0.735	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons