DegronMD

Uniprot ID: Q96QR8

Source protein: Transcriptional activator protein Pur-beta

Source gene: PURB

Class: DEG_APCC_KENBOX_2

Location: 135:139

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.735

ASA_SCORE: 77.2

COIL: 0.658

CONS_SCORE: 0.8353

DSS_SCORE: 0.3255

HELIX: 0.0554

FCONS_SCORE: 1.0609

RIG_SCORE: 0.8382

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L133M	TCGA-BF-A1PU	SKCM	TCGA	LKENQ	DEG_APCC_KENBOX_2	0.2778
p.L133M	DO50278	SKCM	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.2778
p.R145H	TCGA-CR-6477	HNSC	TCGA	LKENQ	DEG_APCC_KENBOX_2	0.1667
p.R145H	DO14216	HNSC	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.1667
p.R147S	DO229036	LICA	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.1111
p.R142S	DO229035	LICA	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.25
p.R129H	DO50696	ORCA	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.1667
p.E137D	SIDM02061	Esophageal Carcinoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	0.6758
p.Y132C	SIDM01617	Endometrial Carcinoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	0.25
p.Y132C	ACH-000994	Endometrial/Uterine Cancer	CCLE	LKENQ	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00577	Transcriptional activator protein Pur-alpha	DEG_APCC_KENBOX_2	159:163	LKENQ	APC,CDC20,FZR1	0.9903	More...
Q5W0Q7	SUMO-specific isopeptidase USPL1	DEG_APCC_KENBOX_2	747:751	LKENQ	APC,CDC20,FZR1	0.8582	More...
Q6ZMT1	SH3 and cysteine-rich domain-containing protein 2	DEG_APCC_KENBOX_2	373:377	LKENQ	APC,CDC20,FZR1	0.8664	More...
Q96QR8	Transcriptional activator protein Pur-beta	DEG_APCC_KENBOX_2	135:139	LKENQ	APC,CDC20,FZR1	0.735	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons