DegronMD

Uniprot ID: Q00577

Source protein: Transcriptional activator protein Pur-alpha

Source gene: PURA

Class: DEG_APCC_KENBOX_2

Location: 159:163

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9903

ASA_SCORE: 81.56

COIL: 0.5856

CONS_SCORE: 0.8328

DSS_SCORE: 0.3669

HELIX: 0.0202

FCONS_SCORE: 1.0776

RIG_SCORE: 0.7946

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R169H	TCGA-5P-A9JZ	KIRP	TCGA	LKENQ	DEG_APCC_KENBOX_2	0.1667
p.R169H	DO223945	KIRP	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.1667
p.L159F	TCGA-61-2113	OV	TCGA	LKENQ	DEG_APCC_KENBOX_2	0.587
p.L159F	DO29328	OV	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.587
p.R153C	TCGA-66-2754	LUSC	TCGA	LKENQ	DEG_APCC_KENBOX_2	0.1667
p.R153C	DO27612	LUSC	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.1667
p.R153S	TCGA-D3-A3C6	SKCM	TCGA	LKENQ	DEG_APCC_KENBOX_2	0.1667
p.R153S	DO37507	SKCM	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.1667
p.R164C	TCGA-GV-A3JZ	BLCA	TCGA	LKENQ	DEG_APCC_KENBOX_2	0.3056
p.R164C	DO773	BLCA	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.3056
p.D158E	TCGA-IB-7651	PAAD	TCGA	LKENQ	DEG_APCC_KENBOX_2	0.3056
p.D158E	DO46657	PAAD	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.3056
p.R164H	DO233644	GACA	ICGC	LKENQ	DEG_APCC_KENBOX_2	0.3056
p.G165S	SIDM01293	Colorectal Carcinoma	GDSC	LKENQ	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00577	Transcriptional activator protein Pur-alpha	DEG_APCC_KENBOX_2	159:163	LKENQ	APC,CDC20,FZR1	0.9903	More...
Q5W0Q7	SUMO-specific isopeptidase USPL1	DEG_APCC_KENBOX_2	747:751	LKENQ	APC,CDC20,FZR1	0.8582	More...
Q6ZMT1	SH3 and cysteine-rich domain-containing protein 2	DEG_APCC_KENBOX_2	373:377	LKENQ	APC,CDC20,FZR1	0.8664	More...
Q96QR8	Transcriptional activator protein Pur-beta	DEG_APCC_KENBOX_2	135:139	LKENQ	APC,CDC20,FZR1	0.735	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons