DegronMD

Uniprot ID: Q6ZMT1

Source protein: SH3 and cysteine-rich domain-containing protein 2

Source gene: STAC2

Class: DEG_APCC_KENBOX_2

Location: 6:10

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9913

ASA_SCORE: 129.42

COIL: 0.8638

CONS_SCORE: 0.6129

DSS_SCORE: 0.905

HELIX: 0.1344

FCONS_SCORE: 1.0957

RIG_SCORE: 0.6055

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K7N	TCGA-05-4396	LUAD	TCGA	EKENE	DEG_APCC_KENBOX_2	0.6918
p.K7N	DO23838	LUAD	ICGC	EKENE	DEG_APCC_KENBOX_2	0.6918
p.P20T	TCGA-IG-A4P3	ESCA	TCGA	EKENE	DEG_APCC_KENBOX_2	0.0556
p.A14V	DO10844	ESAD	ICGC	EKENE	DEG_APCC_KENBOX_2	0.2222
p.A15D	DO228948	LICA	ICGC	EKENE	DEG_APCC_KENBOX_2	0.1944
p.S5R	DO229022	LICA	ICGC	EKENE	DEG_APCC_KENBOX_2	0.3056
p.P11T	SIDM00621	Ewing's Sarcoma	GDSC	EKENE	DEG_APCC_KENBOX_2	0.3056
p.P11T	ACH-002113	Bone Cancer	CCLE	EKENE	DEG_APCC_KENBOX_2	0.3056
p.P11T	EW-13	bone	COSMIC	EKENE	DEG_APCC_KENBOX_2	0.3056
p.S18N	SIDM00217	Colorectal Carcinoma	GDSC	EKENE	DEG_APCC_KENBOX_2	0.5556
p.S18N	ACH-000999	Colon/Colorectal Cancer	CCLE	EKENE	DEG_APCC_KENBOX_2	0.5556
p.S18N	SNU-1040	large_intestine	COSMIC	EKENE	DEG_APCC_KENBOX_2	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13422	DNA-binding protein Ikaros	DEG_APCC_KENBOX_2	300:304	EKENE	APC,CDC20,FZR1	0.962	More...
Q15468	SCL-interrupting locus protein	DEG_APCC_KENBOX_2	1242:1246	EKENE	APC,CDC20,FZR1	0.9516	More...
Q6ZMT1	SH3 and cysteine-rich domain-containing protein 2	DEG_APCC_KENBOX_2	6:10	EKENE	APC,CDC20,FZR1	0.9913	More...
Q96FF9	Sororin	DEG_APCC_KENBOX_2	87:91	EKENE	APC,CDC20,FZR1	0.9924	More...
Q9UKY1	Zinc fingers and homeoboxes protein 1	DEG_APCC_KENBOX_2	209:213	EKENE	APC,CDC20,FZR1	0.9974	More...
Q8IYW2	Cilia- and flagella-associated protein 46	DEG_APCC_KENBOX_2	1380:1384	EKENE	APC,CDC20,FZR1	0.8946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons