DegronMD

Uniprot ID: Q9UKY1

Source protein: Zinc fingers and homeoboxes protein 1

Source gene: ZHX1

Class: DEG_APCC_KENBOX_2

Location: 209:213

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9974

ASA_SCORE: 105.42

COIL: 0.5606

CONS_SCORE: 0.5382

DSS_SCORE: 0.6405

HELIX: 0.4174

FCONS_SCORE: 1.2935

RIG_SCORE: 0.6811

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E211D	TCGA-AJ-A5DW	UCEC	TCGA	EKENE	DEG_APCC_KENBOX_2	0.6758
p.E211D	TCGA-D1-A17Q	UCEC	TCGA	EKENE	DEG_APCC_KENBOX_2	0.6758
p.E211D	DO50075	UCEC	ICGC	EKENE	DEG_APCC_KENBOX_2	0.6758
p.E211D	DO41903	UCEC	ICGC	EKENE	DEG_APCC_KENBOX_2	0.6758
p.R218H	TCGA-CD-A4MG	STAD	TCGA	EKENE	DEG_APCC_KENBOX_2	0.1944
p.R218H	DO48009	STAD	ICGC	EKENE	DEG_APCC_KENBOX_2	0.1944
p.R218H	SIDM00954	Breast Carcinoma	GDSC	EKENE	DEG_APCC_KENBOX_2	0.1944
p.R218H	ACH-002046	Endometrial/Uterine Cancer	CCLE	EKENE	DEG_APCC_KENBOX_2	0.1944
p.R218H	COLO-824	breast	COSMIC	EKENE	DEG_APCC_KENBOX_2	0.1944
p.E209K	TCGA-DA-A1HV	SKCM	TCGA	EKENE	DEG_APCC_KENBOX_2	0.591
p.E209K	DO37659	SKCM	ICGC	EKENE	DEG_APCC_KENBOX_2	0.591
p.E208V	TCGA-DA-A1HV	SKCM	TCGA	EKENE	DEG_APCC_KENBOX_2	0.3056
p.E208V	DO37659	SKCM	ICGC	EKENE	DEG_APCC_KENBOX_2	0.3056
p.R218C	TCGA-EY-A549	UCEC	TCGA	EKENE	DEG_APCC_KENBOX_2	0.1944
p.R218C	DO48174	UCEC	ICGC	EKENE	DEG_APCC_KENBOX_2	0.1944
p.V206I	DO6531	CLLE	ICGC	EKENE	DEG_APCC_KENBOX_2	0.25
p.D205E	DO229025	LICA	ICGC	EKENE	DEG_APCC_KENBOX_2	0.2222
p.P216T	DO229036	LICA	ICGC	EKENE	DEG_APCC_KENBOX_2	0.25
p.E209A	DO220902	MELA	ICGC	EKENE	DEG_APCC_KENBOX_2	0.659
p.V206D	SIDM01009	Neuroblastoma	GDSC	EKENE	DEG_APCC_KENBOX_2	0.25
p.V206D	KELLY	autonomic_ganglia	COSMIC	EKENE	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13422	DNA-binding protein Ikaros	DEG_APCC_KENBOX_2	300:304	EKENE	APC,CDC20,FZR1	0.962	More...
Q15468	SCL-interrupting locus protein	DEG_APCC_KENBOX_2	1242:1246	EKENE	APC,CDC20,FZR1	0.9516	More...
Q6ZMT1	SH3 and cysteine-rich domain-containing protein 2	DEG_APCC_KENBOX_2	6:10	EKENE	APC,CDC20,FZR1	0.9913	More...
Q96FF9	Sororin	DEG_APCC_KENBOX_2	87:91	EKENE	APC,CDC20,FZR1	0.9924	More...
Q9UKY1	Zinc fingers and homeoboxes protein 1	DEG_APCC_KENBOX_2	209:213	EKENE	APC,CDC20,FZR1	0.9974	More...
Q8IYW2	Cilia- and flagella-associated protein 46	DEG_APCC_KENBOX_2	1380:1384	EKENE	APC,CDC20,FZR1	0.8946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons