DegronMD - Q96FF9(CDCA5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P116H	TCGA-A5-A0G2	UCEC	TCGA	VPATPTST	DEG_SCF_FBW7_1	108:115	Mutation rewiring degron network	0.3056
p.P116H	TCGA-A5-A0G2	UCEC	TCGA	AESSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1667
p.P116H	TCGA-XK-AAIW	PRAD	TCGA	VPATPTST	DEG_SCF_FBW7_1	108:115	Mutation rewiring degron network	0.3056
p.P116H	TCGA-XK-AAIW	PRAD	TCGA	AESSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1667
p.P116H	DO51407	PRAD	ICGC	VPATPTST	DEG_SCF_FBW7_1	108:115	Mutation rewiring degron network	0.3056
p.P116H	DO51407	PRAD	ICGC	AESSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1667
p.P116H	DO41235	UCEC	ICGC	VPATPTST	DEG_SCF_FBW7_1	108:115	Mutation rewiring degron network	0.3056
p.P116H	DO41235	UCEC	ICGC	AESSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1667
p.V108I	TCGA-AX-A1C9	UCEC	TCGA	VPATPTST	DEG_SCF_FBW7_1	108:115	Mutation altering degron motif	0.5965
p.V108I	DO43098	UCEC	ICGC	VPATPTST	DEG_SCF_FBW7_1	108:115	Mutation altering degron motif	0.5965
p.E150Q	TCGA-E5-A4U1	BLCA	TCGA	ASTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1944
p.E150Q	DO44061	BLCA	ICGC	ASTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1944
p.S158F	TCGA-FR-A726	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.9093
p.S158F	DO48665	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.9093
p.T151I	TCGA-IB-7651	PAAD	TCGA	ASTST	DEG_SPOP_SBC_1	155:159	Mutation blocking phosphorylation signal	0.6667
p.T151I	DO46657	PAAD	ICGC	ASTST	DEG_SPOP_SBC_1	155:159	Mutation blocking phosphorylation signal	0.6667
p.S156C	TCGA-Q1-A73O	CESC	TCGA	ASTST	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.643
p.S156C	DO51612	CESC	ICGC	ASTST	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.643
p.S126F	TCGA-Q1-A73O	CESC	TCGA	AESSS	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.9093
p.S126F	DO51612	CESC	ICGC	AESSS	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.9093
p.A133T	DO227906	COCA	ICGC	AESSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1389
p.R163Q	DO233884	GACA	ICGC	ASTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.2222
p.R162S	DO228976	LICA	ICGC	ASTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.25
p.T105K	DO229008	LICA	ICGC	VPATPTST	DEG_SCF_FBW7_1	108:115	Mutation blocking phosphorylation signal	0.6944
p.P93S	DO222423	MELA	ICGC	EKENE	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.2778
p.P93S	DO37425	SKCM	ICGC	EKENE	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.2778
p.A133V	DO232224	PBCA	ICGC	AESSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1389
p.F168I	DO219878	SKCA	ICGC	ASTST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0833
p.S83F	DO218856	SKCA	ICGC	EKENE	DEG_APCC_KENBOX_2	87:91	Mutation blocking phosphorylation signal	0.6667
p.R95M	DO229224	THCA	ICGC	EKENE	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.2222
p.Y89H	SIDM02026	Colorectal Carcinoma	GDSC	EKENE	DEG_APCC_KENBOX_2	87:91	Mutation altering degron motif	0.7229
p.R101W	SIDM02013	Colorectal Carcinoma	GDSC	EKENE	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.R101W	SIDM02013	Colorectal Carcinoma	GDSC	VPATPTST	DEG_SCF_FBW7_1	108:115	Mutation rewiring degron network	0.1389
p.P109S	SIDM00092	Ovarian Carcinoma	GDSC	VPATPTST	DEG_SCF_FBW7_1	108:115	Mutation altering degron motif	0.5641
p.P109S	ACH-000617	Ovarian Cancer	CCLE	VPATPTST	DEG_SCF_FBW7_1	108:115	Mutation altering degron motif	0.5641
p.P109S	OVCAR-4	ovary	COSMIC	VPATPTST	DEG_SCF_FBW7_1	108:115	Mutation altering degron motif	0.5641
p.S125C	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.8652
p.S125C	ACH-000945	Lung Cancer	CCLE	AESSS	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.8652
p.S125C	NCI-H650	lung	COSMIC	AESSS	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.8652
p.E123K	SIDM00309	Mesothelioma	GDSC	AESSS	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.591
p.E123K	SIDM01409	Bladder Carcinoma	GDSC	AESSS	DEG_SPOP_SBC_1	122:126	Mutation altering degron motif	0.591
p.R101L	SIDM00927	Small Cell Lung Carcinoma	GDSC	EKENE	DEG_APCC_KENBOX_2	87:91	Mutation rewiring degron network	0.0556
p.R101L	SIDM00927	Small Cell Lung Carcinoma	GDSC	VPATPTST	DEG_SCF_FBW7_1	108:115	Mutation rewiring degron network	0.1389
p.R117P	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VPATPTST	DEG_SCF_FBW7_1	108:115	Mutation rewiring degron network	0.2778
p.R117P	SIDM00951	T-Lymphoblastic Leukemia	GDSC	AESSS	DEG_SPOP_SBC_1	122:126	Mutation rewiring degron network	0.1944

Kaplan plot for CDCA5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDCA5

UniProt ID: Q96FF9

Entrez ID: 113130

Protein name: Sororin (Cell division cycle-associated protein 5) (p35)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDCA5 in