DegronMD

Uniprot ID: Q96FF9

Source protein: Sororin

Source gene: CDCA5

Class: DEG_SCF_FBW7_1

Location: 108:115

E3 ligase: FBXW7

DEGRON score: 0.8634

ASA_SCORE: 90.2875

COIL: 0.9653

CONS_SCORE: 0.5662

DSS_SCORE: 0.7169

HELIX: 0.0091

FCONS_SCORE: 0.9546

RIG_SCORE: 0.5915

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P116H	TCGA-A5-A0G2	UCEC	TCGA	VPATPTST	DEG_SCF_FBW7_1	0.3056
p.P116H	TCGA-XK-AAIW	PRAD	TCGA	VPATPTST	DEG_SCF_FBW7_1	0.3056
p.P116H	DO51407	PRAD	ICGC	VPATPTST	DEG_SCF_FBW7_1	0.3056
p.P116H	DO41235	UCEC	ICGC	VPATPTST	DEG_SCF_FBW7_1	0.3056
p.V108I	TCGA-AX-A1C9	UCEC	TCGA	VPATPTST	DEG_SCF_FBW7_1	0.5965
p.V108I	DO43098	UCEC	ICGC	VPATPTST	DEG_SCF_FBW7_1	0.5965
p.T105K	DO229008	LICA	ICGC	VPATPTST	DEG_SCF_FBW7_1	0.6944
p.R101W	SIDM02013	Colorectal Carcinoma	GDSC	VPATPTST	DEG_SCF_FBW7_1	0.1389
p.P109S	SIDM00092	Ovarian Carcinoma	GDSC	VPATPTST	DEG_SCF_FBW7_1	0.5641
p.P109S	ACH-000617	Ovarian Cancer	CCLE	VPATPTST	DEG_SCF_FBW7_1	0.5641
p.P109S	OVCAR-4	ovary	COSMIC	VPATPTST	DEG_SCF_FBW7_1	0.5641
p.R101L	SIDM00927	Small Cell Lung Carcinoma	GDSC	VPATPTST	DEG_SCF_FBW7_1	0.1389
p.R117P	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VPATPTST	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96FF9	Sororin	DEG_SCF_FBW7_1	108:115	VPATPTST	FBXW7	0.8634	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons