DegronMD - Q15468(STIL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K708R	TCGA-19-5956	GBM	TCGA	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation altering degron motif	0.6126
p.K708R	DO13863	GBM	ICGC	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation altering degron motif	0.6126
p.P516S	TCGA-3H-AB3X	MESO	TCGA	PPAY	ITCH	508:511	Mutation rewiring degron network	0.1944
p.P707T	TCGA-A5-A0G2	UCEC	TCGA	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation altering degron motif	0.7031
p.P707T	DO41235	UCEC	ICGC	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation altering degron motif	0.7031
p.S521N	TCGA-AX-A0J1	UCEC	TCGA	PPAY	ITCH	508:511	Mutation blocking phosphorylation signal	0.5
p.S521N	DO41199	UCEC	ICGC	PPAY	ITCH	508:511	Mutation blocking phosphorylation signal	0.5
p.S719P	TCGA-BG-A222	UCEC	TCGA	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation blocking phosphorylation signal	0.5278
p.S719P	DO42977	UCEC	ICGC	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation blocking phosphorylation signal	0.5278
p.I1252T	TCGA-BR-7851	STAD	TCGA	ITIFPE	LIG_APCC_ABBA_1	1249:1254	Mutation altering degron motif	0.7078
p.I1252T	DO38711	STAD	ICGC	ITIFPE	LIG_APCC_ABBA_1	1249:1254	Mutation altering degron motif	0.7078
p.P1254T	TCGA-CA-6718	COAD	TCGA	ITIFPE	LIG_APCC_ABBA_1	1249:1254	Mutation altering degron motif	0.7031
p.P1254T	DO7801	COAD	ICGC	ITIFPE	LIG_APCC_ABBA_1	1249:1254	Mutation altering degron motif	0.7031
p.R1232Q	TCGA-D1-A17Q	UCEC	TCGA	EKENE	DEG_APCC_KENBOX_2	1242:1246	Mutation rewiring degron network	0.0556
p.R1232Q	DO41903	UCEC	ICGC	EKENE	DEG_APCC_KENBOX_2	1242:1246	Mutation rewiring degron network	0.0556
p.P1254S	TCGA-D3-A8GM	SKCM	TCGA	ITIFPE	LIG_APCC_ABBA_1	1249:1254	Mutation altering degron motif	0.6752
p.P1254S	DO50288	SKCM	ICGC	ITIFPE	LIG_APCC_ABBA_1	1249:1254	Mutation altering degron motif	0.6752
p.P509L	TCGA-DD-AACB	LIHC	TCGA	PPAY	ITCH	508:511	Mutation altering degron motif	0.7582
p.P509L	DO52197	LIHC	ICGC	PPAY	ITCH	508:511	Mutation altering degron motif	0.7582
p.P720A	TCGA-XF-AAML	BLCA	TCGA	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation rewiring degron network	0.0556
p.P720A	DO51933	BLCA	ICGC	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation rewiring degron network	0.0556
p.S711L	TCGA-XF-AAML	BLCA	TCGA	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation rewiring degron network	0.3056
p.S711L	DO51933	BLCA	ICGC	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation rewiring degron network	0.3056
p.N696D	DO50451	ESAD	ICGC	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation rewiring degron network	0.1111
p.P699T	DO228948	LICA	ICGC	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation rewiring degron network	0.1944
p.Q1258K	DO228971	LICA	ICGC	ITIFPE	LIG_APCC_ABBA_1	1249:1254	Mutation rewiring degron network	0.2222
p.H705N	DO228971	LICA	ICGC	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation altering degron motif	0.6312
p.L499F	DO222880	MELA	ICGC	PPAY	ITCH	508:511	Mutation rewiring degron network	0.0833
p.G714R	DO232224	PBCA	ICGC	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation rewiring degron network	0.2222
p.E1243D	SIDM00193	Colorectal Carcinoma	GDSC	EKENE	DEG_APCC_KENBOX_2	1242:1246	Mutation altering degron motif	0.6758
p.E1243D	ACH-000991	Colon/Colorectal Cancer	CCLE	EKENE	DEG_APCC_KENBOX_2	1242:1246	Mutation altering degron motif	0.6758
p.E1243D	SNU-81	large intestine	COSMIC	EKENE	DEG_APCC_KENBOX_2	1242:1246	Mutation altering degron motif	0.6758
p.H1241L	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	EKENE	DEG_APCC_KENBOX_2	1242:1246	Mutation rewiring degron network	0.3056
p.H1241L	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	ITIFPE	LIG_APCC_ABBA_1	1249:1254	Mutation rewiring degron network	0.1111
p.H1241L	ACH-000917	Esophageal Cancer	CCLE	EKENE	DEG_APCC_KENBOX_2	1242:1246	Mutation rewiring degron network	0.3056
p.H1241L	ACH-000917	Esophageal Cancer	CCLE	ITIFPE	LIG_APCC_ABBA_1	1249:1254	Mutation rewiring degron network	0.1111
p.H1241L	TE-4	oesophagus	COSMIC	EKENE	DEG_APCC_KENBOX_2	1242:1246	Mutation rewiring degron network	0.3056
p.H1241L	TE-4	oesophagus	COSMIC	ITIFPE	LIG_APCC_ABBA_1	1249:1254	Mutation rewiring degron network	0.1111
p.H705R	SIDM00498	Colorectal Carcinoma	GDSC	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation altering degron motif	0.7133
p.H705R	ACH-000970	Colon/Colorectal Cancer	CCLE	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation altering degron motif	0.7133
p.H705R	SNU-C5	large intestine	COSMIC	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation altering degron motif	0.7133
p.A1236P	SIDM00959	Acute Myeloid Leukemia	GDSC	EKENE	DEG_APCC_KENBOX_2	1242:1246	Mutation rewiring degron network	0.1667
p.A1236P	ACH-000641	Leukemia	CCLE	EKENE	DEG_APCC_KENBOX_2	1242:1246	Mutation rewiring degron network	0.1667
p.A1236P	CMK	haematopoietic and lymphoid tissue	COSMIC	EKENE	DEG_APCC_KENBOX_2	1242:1246	Mutation rewiring degron network	0.1667
p.E1242D	SNU-81	large intestine	COSMIC	EKENE	DEG_APCC_KENBOX_2	1242:1246	Mutation altering degron motif	0.5647
p.F1241C	HCC2998	large intestine	COSMIC	EKENE	DEG_APCC_KENBOX_2	1242:1246	Mutation rewiring degron network	0.3056
p.F1241C	HCC2998	large intestine	COSMIC	ITIFPE	LIG_APCC_ABBA_1	1249:1254	Mutation rewiring degron network	0.1111
p.K1239N	SNU-C5	large intestine	COSMIC	EKENE	DEG_APCC_KENBOX_2	1242:1246	Mutation rewiring degron network	0.25
p.K1239N	SNU-C5	large intestine	COSMIC	ITIFPE	LIG_APCC_ABBA_1	1249:1254	Mutation rewiring degron network	0.0556
p.L511P	HCT-15	large intestine	COSMIC	PPAY	ITCH	508:511	Mutation altering degron motif	0.7582
p.A699T	SNG-M	endometrium	COSMIC	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation rewiring degron network	0.1944
p.H1240L	TE-4	oesophagus	COSMIC	EKENE	DEG_APCC_KENBOX_2	1242:1246	Mutation rewiring degron network	0.2778
p.H1240L	TE-4	oesophagus	COSMIC	ITIFPE	LIG_APCC_ABBA_1	1249:1254	Mutation rewiring degron network	0.0833
p.A1235P	CMK	haematopoietic and lymphoid tissue	COSMIC	EKENE	DEG_APCC_KENBOX_2	1242:1246	Mutation rewiring degron network	0.1389
p.Q694L	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	MHTPKTE	DEG_SCF_FBW7_2	704:710	Mutation rewiring degron network	0.0556

Kaplan plot for STIL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STIL

UniProt ID: Q15468

Entrez ID: 6491

Protein name: SCL-interrupting locus protein (TAL-1-interrupting locus protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STIL in