DegronMD

Uniprot ID: Q15468

Source protein: SCL-interrupting locus protein

Source gene: STIL

Class: DEG_SCF_FBW7_2

Location: 704:710

E3 ligase: FBXW7

DEGRON score: 0.9718

ASA_SCORE: 105.2714

COIL: 0.9326

CONS_SCORE: 0.3631

DSS_SCORE: 0.4095

HELIX: 0.025

FCONS_SCORE: 1.0215

RIG_SCORE: 0.7111

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K708R	TCGA-19-5956	GBM	TCGA	MHTPKTE	DEG_SCF_FBW7_2	0.6126
p.K708R	DO13863	GBM	ICGC	MHTPKTE	DEG_SCF_FBW7_2	0.6126
p.P707T	TCGA-A5-A0G2	UCEC	TCGA	MHTPKTE	DEG_SCF_FBW7_2	0.7031
p.P707T	DO41235	UCEC	ICGC	MHTPKTE	DEG_SCF_FBW7_2	0.7031
p.S719P	TCGA-BG-A222	UCEC	TCGA	MHTPKTE	DEG_SCF_FBW7_2	0.5278
p.S719P	DO42977	UCEC	ICGC	MHTPKTE	DEG_SCF_FBW7_2	0.5278
p.P720A	TCGA-XF-AAML	BLCA	TCGA	MHTPKTE	DEG_SCF_FBW7_2	0.0556
p.P720A	DO51933	BLCA	ICGC	MHTPKTE	DEG_SCF_FBW7_2	0.0556
p.S711L	TCGA-XF-AAML	BLCA	TCGA	MHTPKTE	DEG_SCF_FBW7_2	0.3056
p.S711L	DO51933	BLCA	ICGC	MHTPKTE	DEG_SCF_FBW7_2	0.3056
p.N696D	DO50451	ESAD	ICGC	MHTPKTE	DEG_SCF_FBW7_2	0.1111
p.P699T	DO228948	LICA	ICGC	MHTPKTE	DEG_SCF_FBW7_2	0.1944
p.H705N	DO228971	LICA	ICGC	MHTPKTE	DEG_SCF_FBW7_2	0.6312
p.G714R	DO232224	PBCA	ICGC	MHTPKTE	DEG_SCF_FBW7_2	0.2222
p.H705R	SIDM00498	Colorectal Carcinoma	GDSC	MHTPKTE	DEG_SCF_FBW7_2	0.7133
p.H705R	ACH-000970	Colon/Colorectal Cancer	CCLE	MHTPKTE	DEG_SCF_FBW7_2	0.7133
p.H705R	SNU-C5	large_intestine	COSMIC	MHTPKTE	DEG_SCF_FBW7_2	0.7133
p.A699T	SNG-M	endometrium	COSMIC	MHTPKTE	DEG_SCF_FBW7_2	0.1944
p.Q694L	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	MHTPKTE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15468	SCL-interrupting locus protein	DEG_SCF_FBW7_2	704:710	MHTPKTE	FBXW7	0.9718	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons