DegronMD

Uniprot ID: Q15468

Source protein: SCL-interrupting locus protein

Source gene: STIL

Class: DEG_APCC_KENBOX_2

Location: 1242:1246

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9516

ASA_SCORE: 114.24

COIL: 0.805

CONS_SCORE: 0.2697

DSS_SCORE: 0.6164

HELIX: 0.14

FCONS_SCORE: 0.8911

RIG_SCORE: 0.6611

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1232Q	TCGA-D1-A17Q	UCEC	TCGA	EKENE	DEG_APCC_KENBOX_2	0.0556
p.R1232Q	DO41903	UCEC	ICGC	EKENE	DEG_APCC_KENBOX_2	0.0556
p.E1243D	SIDM00193	Colorectal Carcinoma	GDSC	EKENE	DEG_APCC_KENBOX_2	0.6758
p.E1243D	ACH-000991	Colon/Colorectal Cancer	CCLE	EKENE	DEG_APCC_KENBOX_2	0.6758
p.E1243D	SNU-81	large_intestine	COSMIC	EKENE	DEG_APCC_KENBOX_2	0.6758
p.H1241L	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	EKENE	DEG_APCC_KENBOX_2	0.3056
p.H1241L	ACH-000917	Esophageal Cancer	CCLE	EKENE	DEG_APCC_KENBOX_2	0.3056
p.H1241L	TE-4	oesophagus	COSMIC	EKENE	DEG_APCC_KENBOX_2	0.3056
p.A1236P	SIDM00959	Acute Myeloid Leukemia	GDSC	EKENE	DEG_APCC_KENBOX_2	0.1667
p.A1236P	ACH-000641	Leukemia	CCLE	EKENE	DEG_APCC_KENBOX_2	0.1667
p.A1236P	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	EKENE	DEG_APCC_KENBOX_2	0.1667
p.E1242D	SNU-81	large_intestine	COSMIC	EKENE	DEG_APCC_KENBOX_2	0.5647
p.F1241C	HCC2998	large_intestine	COSMIC	EKENE	DEG_APCC_KENBOX_2	0.3056
p.K1239N	SNU-C5	large_intestine	COSMIC	EKENE	DEG_APCC_KENBOX_2	0.25
p.H1240L	TE-4	oesophagus	COSMIC	EKENE	DEG_APCC_KENBOX_2	0.2778
p.A1235P	CMK	haematopoietic_and_lymphoid_tissue	COSMIC	EKENE	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13422	DNA-binding protein Ikaros	DEG_APCC_KENBOX_2	300:304	EKENE	APC,CDC20,FZR1	0.962	More...
Q15468	SCL-interrupting locus protein	DEG_APCC_KENBOX_2	1242:1246	EKENE	APC,CDC20,FZR1	0.9516	More...
Q6ZMT1	SH3 and cysteine-rich domain-containing protein 2	DEG_APCC_KENBOX_2	6:10	EKENE	APC,CDC20,FZR1	0.9913	More...
Q96FF9	Sororin	DEG_APCC_KENBOX_2	87:91	EKENE	APC,CDC20,FZR1	0.9924	More...
Q9UKY1	Zinc fingers and homeoboxes protein 1	DEG_APCC_KENBOX_2	209:213	EKENE	APC,CDC20,FZR1	0.9974	More...
Q8IYW2	Cilia- and flagella-associated protein 46	DEG_APCC_KENBOX_2	1380:1384	EKENE	APC,CDC20,FZR1	0.8946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons