DegronMD - Q9UKY1(ZHX1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R581C	TCGA-14-1455	GBM	TCGA	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation rewiring degron network	0.0556
p.R581C	DO12820	GBM	ICGC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation rewiring degron network	0.0556
p.R581C	SIDM00217	Colorectal Carcinoma	GDSC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation rewiring degron network	0.0556
p.R581C	ACH-000999	Colon/Colorectal Cancer	CCLE	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation rewiring degron network	0.0556
p.R581C	SNU-1040	large intestine	COSMIC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation rewiring degron network	0.0556
p.P557L	TCGA-43-A56U	LUSC	TCGA	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation rewiring degron network	0.1389
p.P557L	DO49083	LUSC	ICGC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation rewiring degron network	0.1389
p.S728N	TCGA-AA-A010	COAD	TCGA	ANSSS	DEG_SPOP_SBC_1	729:733	Mutation rewiring degron network	0.3056
p.E211D	TCGA-AJ-A5DW	UCEC	TCGA	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation altering degron motif	0.6758
p.E211D	TCGA-D1-A17Q	UCEC	TCGA	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation altering degron motif	0.6758
p.E211D	DO50075	UCEC	ICGC	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation altering degron motif	0.6758
p.E211D	DO41903	UCEC	ICGC	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation altering degron motif	0.6758
p.F564C	TCGA-CA-6717	COAD	TCGA	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation altering degron motif	0.5996
p.F564C	DO8264	COAD	ICGC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation altering degron motif	0.5996
p.R218H	TCGA-CD-A4MG	STAD	TCGA	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation rewiring degron network	0.1944
p.R218H	DO48009	STAD	ICGC	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation rewiring degron network	0.1944
p.R218H	SIDM00954	Breast Carcinoma	GDSC	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation rewiring degron network	0.1944
p.R218H	ACH-002046	Endometrial/Uterine Cancer	CCLE	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation rewiring degron network	0.1944
p.R218H	COLO-824	breast	COSMIC	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation rewiring degron network	0.1944
p.Y723H	TCGA-CG-4442	STAD	TCGA	ANSSS	DEG_SPOP_SBC_1	729:733	Mutation rewiring degron network	0.1667
p.Y723H	DO38380	STAD	ICGC	ANSSS	DEG_SPOP_SBC_1	729:733	Mutation rewiring degron network	0.1667
p.Q727E	TCGA-CN-5369	HNSC	TCGA	ANSSS	DEG_SPOP_SBC_1	729:733	Mutation rewiring degron network	0.2778
p.Q727E	DO16069	HNSC	ICGC	ANSSS	DEG_SPOP_SBC_1	729:733	Mutation rewiring degron network	0.2778
p.E209K	TCGA-DA-A1HV	SKCM	TCGA	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation altering degron motif	0.591
p.E209K	DO37659	SKCM	ICGC	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation altering degron motif	0.591
p.E208V	TCGA-DA-A1HV	SKCM	TCGA	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation rewiring degron network	0.3056
p.E208V	DO37659	SKCM	ICGC	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation rewiring degron network	0.3056
p.E574G	TCGA-EE-A17X	SKCM	TCGA	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation rewiring degron network	0.25
p.E574G	DO37931	SKCM	ICGC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation rewiring degron network	0.25
p.A729T	TCGA-EO-A22T	UCEC	TCGA	ANSSS	DEG_SPOP_SBC_1	729:733	Mutation altering degron motif	0.7139
p.A729T	DO42320	UCEC	ICGC	ANSSS	DEG_SPOP_SBC_1	729:733	Mutation altering degron motif	0.7139
p.A729T	SIDM00153	T-Lymphoblastic Leukemia	GDSC	ANSSS	DEG_SPOP_SBC_1	729:733	Mutation altering degron motif	0.7139
p.A729T	ACH-000964	Leukemia	CCLE	ANSSS	DEG_SPOP_SBC_1	729:733	Mutation altering degron motif	0.7139
p.R218C	TCGA-EY-A549	UCEC	TCGA	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation rewiring degron network	0.1944
p.R218C	DO48174	UCEC	ICGC	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation rewiring degron network	0.1944
p.P563L	TCGA-GU-AATQ	BLCA	TCGA	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation rewiring degron network	0.3056
p.P563L	DO51896	BLCA	ICGC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation rewiring degron network	0.3056
p.W722C	TCGA-NJ-A4YP	LUAD	TCGA	ANSSS	DEG_SPOP_SBC_1	729:733	Mutation rewiring degron network	0.1389
p.W722C	DO218943	LUAD	ICGC	ANSSS	DEG_SPOP_SBC_1	729:733	Mutation rewiring degron network	0.1389
p.E578G	DO225337	BRCA	ICGC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation rewiring degron network	0.1389
p.V206I	DO6531	CLLE	ICGC	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation rewiring degron network	0.25
p.N719K	DO234455	ESAD	ICGC	ANSSS	DEG_SPOP_SBC_1	729:733	Mutation rewiring degron network	0.0556
p.S728R	DO228948	LICA	ICGC	ANSSS	DEG_SPOP_SBC_1	729:733	Mutation rewiring degron network	0.3056
p.D205E	DO229025	LICA	ICGC	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation rewiring degron network	0.2222
p.P216T	DO229036	LICA	ICGC	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation rewiring degron network	0.25
p.P563S	DO220851	MELA	ICGC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation rewiring degron network	0.3056
p.E209A	DO220902	MELA	ICGC	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation altering degron motif	0.659
p.Y725C	SIDM00049	Colorectal Carcinoma	GDSC	ANSSS	DEG_SPOP_SBC_1	729:733	Mutation rewiring degron network	0.2222
p.Y725C	ACH-002233	Colon/Colorectal Cancer	CCLE	ANSSS	DEG_SPOP_SBC_1	729:733	Mutation rewiring degron network	0.2222
p.Y725C	DIFI	large intestine	COSMIC	ANSSS	DEG_SPOP_SBC_1	729:733	Mutation rewiring degron network	0.2222
p.V206D	SIDM01009	Neuroblastoma	GDSC	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation rewiring degron network	0.25
p.V206D	KELLY	autonomic ganglia	COSMIC	EKENE	DEG_APCC_KENBOX_2	209:213	Mutation rewiring degron network	0.25
p.K571T	SIDM00118	Colorectal Carcinoma	GDSC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation altering degron motif	0.7306
p.K571T	ACH-001081	Colon/Colorectal Cancer	CCLE	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation altering degron motif	0.7306
p.K571T	HCC2998	large intestine	COSMIC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation altering degron motif	0.7306
p.L580R	SIDM01450	Gastric Carcinoma	GDSC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation rewiring degron network	0.0833
p.L580R	ACH-000898	Gastric Cancer	CCLE	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	564:571	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZHX1

UniProt ID: Q9UKY1

Entrez ID: 11244

Protein name: Zinc fingers and homeoboxes protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZHX1 in