DegronMD

Uniprot ID: Q9UKY1

Source protein: Zinc fingers and homeoboxes protein 1

Source gene: ZHX1

Class: DEG_SCF_SKP2-CKS1_1

Location: 564:571

E3 ligase: SKP2,CSK1

DEGRON score: 0.9675

ASA_SCORE: 86.9

COIL: 0.8049

CONS_SCORE: 0.5551

DSS_SCORE: 0.5801

HELIX: 0.1391

FCONS_SCORE: 0.9565

RIG_SCORE: 0.761

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R581C	TCGA-14-1455	GBM	TCGA	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.R581C	DO12820	GBM	ICGC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.R581C	SIDM00217	Colorectal Carcinoma	GDSC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.R581C	ACH-000999	Colon/Colorectal Cancer	CCLE	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.R581C	SNU-1040	large_intestine	COSMIC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.P557L	TCGA-43-A56U	LUSC	TCGA	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.1389
p.P557L	DO49083	LUSC	ICGC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.1389
p.F564C	TCGA-CA-6717	COAD	TCGA	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.5996
p.F564C	DO8264	COAD	ICGC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.5996
p.E574G	TCGA-EE-A17X	SKCM	TCGA	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.25
p.E574G	DO37931	SKCM	ICGC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.25
p.P563L	TCGA-GU-AATQ	BLCA	TCGA	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.3056
p.P563L	DO51896	BLCA	ICGC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.3056
p.E578G	DO225337	BRCA	ICGC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.1389
p.P563S	DO220851	MELA	ICGC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.3056
p.K571T	SIDM00118	Colorectal Carcinoma	GDSC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.7306
p.K571T	ACH-001081	Colon/Colorectal Cancer	CCLE	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.7306
p.K571T	HCC2998	large_intestine	COSMIC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.7306
p.L580R	SIDM01450	Gastric Carcinoma	GDSC	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.0833
p.L580R	ACH-000898	Gastric Cancer	CCLE	FPDFTPQK	DEG_SCF_SKP2-CKS1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKY1	Zinc fingers and homeoboxes protein 1	DEG_SCF_SKP2-CKS1_1	564:571	FPDFTPQK	SKP2,CSK1	0.9675	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons