DegronMD

Uniprot ID: Q9UKY1

Source protein: Zinc fingers and homeoboxes protein 1

Source gene: ZHX1

Class: DEG_SPOP_SBC_1

Location: 729:733

E3 ligase: SPOP

DEGRON score: 0.8431

ASA_SCORE: 77

COIL: 0.88

CONS_SCORE: 0.4292

DSS_SCORE: 0.1996

HELIX: 0.0956

FCONS_SCORE: 0.8511

RIG_SCORE: 0.7026

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S728N	TCGA-AA-A010	COAD	TCGA	ANSSS	DEG_SPOP_SBC_1	0.3056
p.Y723H	TCGA-CG-4442	STAD	TCGA	ANSSS	DEG_SPOP_SBC_1	0.1667
p.Y723H	DO38380	STAD	ICGC	ANSSS	DEG_SPOP_SBC_1	0.1667
p.Q727E	TCGA-CN-5369	HNSC	TCGA	ANSSS	DEG_SPOP_SBC_1	0.2778
p.Q727E	DO16069	HNSC	ICGC	ANSSS	DEG_SPOP_SBC_1	0.2778
p.A729T	TCGA-EO-A22T	UCEC	TCGA	ANSSS	DEG_SPOP_SBC_1	0.7139
p.A729T	DO42320	UCEC	ICGC	ANSSS	DEG_SPOP_SBC_1	0.7139
p.A729T	SIDM00153	T-Lymphoblastic Leukemia	GDSC	ANSSS	DEG_SPOP_SBC_1	0.7139
p.A729T	ACH-000964	Leukemia	CCLE	ANSSS	DEG_SPOP_SBC_1	0.7139
p.W722C	TCGA-NJ-A4YP	LUAD	TCGA	ANSSS	DEG_SPOP_SBC_1	0.1389
p.W722C	DO218943	LUAD	ICGC	ANSSS	DEG_SPOP_SBC_1	0.1389
p.N719K	DO234455	ESAD	ICGC	ANSSS	DEG_SPOP_SBC_1	0.0556
p.S728R	DO228948	LICA	ICGC	ANSSS	DEG_SPOP_SBC_1	0.3056
p.Y725C	SIDM00049	Colorectal Carcinoma	GDSC	ANSSS	DEG_SPOP_SBC_1	0.2222
p.Y725C	ACH-002233	Colon/Colorectal Cancer	CCLE	ANSSS	DEG_SPOP_SBC_1	0.2222
p.Y725C	DIFI	large_intestine	COSMIC	ANSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22670	MHC class II regulatory factor RFX1	DEG_SPOP_SBC_1	213:217	ANSSS	SPOP	0.9966	More...
P42694	Probable helicase with zinc finger domain	DEG_SPOP_SBC_1	1879:1883	ANSSS	SPOP	0.986	More...
P80192	Mitogen-activated protein kinase kinase kinase 9	DEG_SPOP_SBC_1	1021:1025	ANSSS	SPOP	0.9968	More...
Q06945	Transcription factor SOX-4	DEG_SPOP_SBC_1	139:143	ANSSS	SPOP	0.9719	More...
Q6UWB1	Interleukin-27 receptor subunit alpha	DEG_SPOP_SBC_1	562:566	ANSSS	SPOP	0.7903	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	551:555	ANSSS	SPOP	0.983	More...
Q8IZW8	Tensin-4	DEG_SPOP_SBC_1	311:315	ANSSS	SPOP	0.8185	More...
Q99743	Neuronal PAS domain-containing protein 2	DEG_SPOP_SBC_1	720:724	ANSSS	SPOP	0.9105	More...
Q9BRS8	La-related protein 6	DEG_SPOP_SBC_1	336:340	ANSSS	SPOP	0.9686	More...
Q9HCD5	Nuclear receptor coactivator 5	DEG_SPOP_SBC_1	446:450	ANSSS	SPOP	0.8794	More...
Q9UKY1	Zinc fingers and homeoboxes protein 1	DEG_SPOP_SBC_1	729:733	ANSSS	SPOP	0.8431	More...
Q9Y2F9	BTB/POZ domain-containing protein 3	DEG_SPOP_SBC_1	73:77	ANSSS	SPOP	0.9841	More...
Q9Y4F3	Meiosis regulator and mRNA stability factor 1	DEG_SPOP_SBC_1	775:779	ANSSS	SPOP	0.9091	More...
Q9H1C0	Lysophosphatidic acid receptor 5	DEG_SPOP_SBC_1	3:7	ANSSS	SPOP	0.6526	More...
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_SPOP_SBC_1	429:433	ANSSS	SPOP	0.756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons