DegronMD

Uniprot ID: Q99743

Source protein: Neuronal PAS domain-containing protein 2

Source gene: NPAS2

Class: DEG_SPOP_SBC_1

Location: 720:724

E3 ligase: SPOP

DEGRON score: 0.9105

ASA_SCORE: 87.86

COIL: 0.9346

CONS_SCORE: 0.3881

DSS_SCORE: 0.5572

HELIX: 0.0476

FCONS_SCORE: 0.972

RIG_SCORE: 0.5985

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P726L	TCGA-2W-A8YY	CESC	TCGA	ANSSS	DEG_SPOP_SBC_1	0.2778
p.P726L	DO223732	CESC	ICGC	ANSSS	DEG_SPOP_SBC_1	0.2778
p.V729F	TCGA-95-7039	LUAD	TCGA	ANSSS	DEG_SPOP_SBC_1	0.1944
p.V729F	DO228974	LICA	ICGC	ANSSS	DEG_SPOP_SBC_1	0.1944
p.V729F	DO23907	LUAD	ICGC	ANSSS	DEG_SPOP_SBC_1	0.1944
p.M727L	TCGA-AA-3819	COAD	TCGA	ANSSS	DEG_SPOP_SBC_1	0.25
p.M727L	DO10590	COAD	ICGC	ANSSS	DEG_SPOP_SBC_1	0.25
p.V729I	TCGA-D1-A0ZQ	UCEC	TCGA	ANSSS	DEG_SPOP_SBC_1	0.1944
p.V729I	DO41879	UCEC	ICGC	ANSSS	DEG_SPOP_SBC_1	0.1944
p.L730M	TCGA-EE-A2MN	SKCM	TCGA	ANSSS	DEG_SPOP_SBC_1	0.1667
p.L730M	DO37423	SKCM	ICGC	ANSSS	DEG_SPOP_SBC_1	0.1667
p.V711M	TCGA-FI-A2D0	UCEC	TCGA	ANSSS	DEG_SPOP_SBC_1	0.0833
p.V711M	DO43891	UCEC	ICGC	ANSSS	DEG_SPOP_SBC_1	0.0833
p.P728L	TCGA-FS-A1ZN	SKCM	TCGA	ANSSS	DEG_SPOP_SBC_1	0.2222
p.P728L	DO38165	SKCM	ICGC	ANSSS	DEG_SPOP_SBC_1	0.2222
p.P715L	TCGA-YD-A89C	SKCM	TCGA	ANSSS	DEG_SPOP_SBC_1	0.1944
p.P715L	DO219501	SKCM	ICGC	ANSSS	DEG_SPOP_SBC_1	0.1944
p.S723N	DO230309	COCA	ICGC	ANSSS	DEG_SPOP_SBC_1	0.7069
p.M732R	DO224563	LUSC	ICGC	ANSSS	DEG_SPOP_SBC_1	0.1111
p.A720T	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	ANSSS	DEG_SPOP_SBC_1	0.7139
p.A720T	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	ANSSS	DEG_SPOP_SBC_1	0.7139
p.A720T	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	ANSSS	DEG_SPOP_SBC_1	0.7139
p.P719H	SIDM00783	Colorectal Carcinoma	GDSC	ANSSS	DEG_SPOP_SBC_1	0.3056
p.P719H	ACH-000971	Colon/Colorectal Cancer	CCLE	ANSSS	DEG_SPOP_SBC_1	0.3056
p.P719H	HCT-116	large_intestine	COSMIC	ANSSS	DEG_SPOP_SBC_1	0.3056
p.P728S	ACH-001392	Breast Cancer	CCLE	ANSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22670	MHC class II regulatory factor RFX1	DEG_SPOP_SBC_1	213:217	ANSSS	SPOP	0.9966	More...
P42694	Probable helicase with zinc finger domain	DEG_SPOP_SBC_1	1879:1883	ANSSS	SPOP	0.986	More...
P80192	Mitogen-activated protein kinase kinase kinase 9	DEG_SPOP_SBC_1	1021:1025	ANSSS	SPOP	0.9968	More...
Q06945	Transcription factor SOX-4	DEG_SPOP_SBC_1	139:143	ANSSS	SPOP	0.9719	More...
Q6UWB1	Interleukin-27 receptor subunit alpha	DEG_SPOP_SBC_1	562:566	ANSSS	SPOP	0.7903	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	551:555	ANSSS	SPOP	0.983	More...
Q8IZW8	Tensin-4	DEG_SPOP_SBC_1	311:315	ANSSS	SPOP	0.8185	More...
Q99743	Neuronal PAS domain-containing protein 2	DEG_SPOP_SBC_1	720:724	ANSSS	SPOP	0.9105	More...
Q9BRS8	La-related protein 6	DEG_SPOP_SBC_1	336:340	ANSSS	SPOP	0.9686	More...
Q9HCD5	Nuclear receptor coactivator 5	DEG_SPOP_SBC_1	446:450	ANSSS	SPOP	0.8794	More...
Q9UKY1	Zinc fingers and homeoboxes protein 1	DEG_SPOP_SBC_1	729:733	ANSSS	SPOP	0.8431	More...
Q9Y2F9	BTB/POZ domain-containing protein 3	DEG_SPOP_SBC_1	73:77	ANSSS	SPOP	0.9841	More...
Q9Y4F3	Meiosis regulator and mRNA stability factor 1	DEG_SPOP_SBC_1	775:779	ANSSS	SPOP	0.9091	More...
Q9H1C0	Lysophosphatidic acid receptor 5	DEG_SPOP_SBC_1	3:7	ANSSS	SPOP	0.6526	More...
Q9P2F8	Signal-induced proliferation-associated 1-like protein 2	DEG_SPOP_SBC_1	429:433	ANSSS	SPOP	0.756	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons