DegronMD - P22670(RFX1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T326M	TCGA-44-6144	LUAD	TCGA	PETPLYT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.2778
p.T326M	DO24190	LUAD	ICGC	PETPLYT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.2778
p.A327G	TCGA-86-8073	LUAD	TCGA	PETPLYT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.25
p.A327G	DO23624	LUAD	ICGC	PETPLYT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.25
p.P210L	TCGA-AZ-6598	COAD	TCGA	ANSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.25
p.P210L	DO10276	COAD	ICGC	ANSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.25
p.V360L	TCGA-CZ-4859	KIRC	TCGA	VASST	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.1667
p.V360L	DO18602	KIRC	ICGC	VASST	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.1667
p.P357H	TCGA-DA-A1IB	SKCM	TCGA	VSTPATS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.0556
p.P357H	TCGA-DA-A1IB	SKCM	TCGA	VASST	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.0833
p.P357H	DO38033	SKCM	ICGC	VSTPATS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.0556
p.P357H	DO38033	SKCM	ICGC	VASST	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.0833
p.T337A	TCGA-DI-A1BU	UCEC	TCGA	VSTPATS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.2222
p.T337A	DO42023	UCEC	ICGC	VSTPATS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.2222
p.T370A	DO48362	BLCA	ICGC	VASST	DEG_SPOP_SBC_1	366:370	Mutation altering degron motif	0.7139
p.T370A	DO228483	BRCA	ICGC	VASST	DEG_SPOP_SBC_1	366:370	Mutation altering degron motif	0.7139
p.T370A	DO229013	COCA	ICGC	VASST	DEG_SPOP_SBC_1	366:370	Mutation altering degron motif	0.7139
p.T370A	DO229016	COCA	ICGC	VASST	DEG_SPOP_SBC_1	366:370	Mutation altering degron motif	0.7139
p.T370A	DO229003	COCA	ICGC	VASST	DEG_SPOP_SBC_1	366:370	Mutation altering degron motif	0.7139
p.T370A	DO229005	COCA	ICGC	VASST	DEG_SPOP_SBC_1	366:370	Mutation altering degron motif	0.7139
p.T370A	DO230529	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	366:370	Mutation altering degron motif	0.7139
p.T370A	DO230931	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	366:370	Mutation altering degron motif	0.7139
p.T370A	DO231049	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	366:370	Mutation altering degron motif	0.7139
p.M358I	DO3614	BRCA	ICGC	VASST	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.1111
p.G336C	DO230326	COCA	ICGC	VSTPATS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.1944
p.R311H	DO233898	GACA	ICGC	PETPLYT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.1389
p.H203L	DO228206	LICA	ICGC	ANSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.0556
p.A213D	DO228952	LICA	ICGC	ANSSS	DEG_SPOP_SBC_1	213:217	Mutation altering degron motif	0.7793
p.Q208K	DO228978	LICA	ICGC	ANSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1944
p.S330R	DO229029	LICA	ICGC	PETPLYT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.1667
p.A349E	DO229028	LICA	ICGC	VSTPATS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.2778
p.T337K	DO229028	LICA	ICGC	VSTPATS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.2222
p.T220K	DO229031	LICA	ICGC	ANSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.25
p.S369F	DO222683	MELA	ICGC	VASST	DEG_SPOP_SBC_1	366:370	Mutation altering degron motif	0.7982
p.G362C	DO232846	NACA	ICGC	VASST	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.2222
p.Q348K	DO50687	ORCA	ICGC	VSTPATS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.3056
p.L322M	DO232761	PBCA	ICGC	PETPLYT	DEG_SCF_FBW7_1	318:324	Mutation altering degron motif	0.5999
p.I310M	DO229216	THCA	ICGC	PETPLYT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.1111
p.S377R	DO229218	THCA	ICGC	VASST	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.1389
p.Q325R	DO229221	THCA	ICGC	PETPLYT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.3056
p.A351V	DO229224	THCA	ICGC	VSTPATS	DEG_SCF_FBW7_1	341:347	Mutation rewiring degron network	0.2222
p.Q325H	DO229245	THCA	ICGC	PETPLYT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.3056
p.S361F	DO229250	THCA	ICGC	VASST	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.1944
p.Q325E	SIDM01220	Glioma	GDSC	PETPLYT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.3056
p.Q325E	LNZTA3WT4	central nervous system	COSMIC	PETPLYT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.3056
p.A223G	ACH-000972	Endometrial/Uterine Cancer	CCLE	ANSSS	DEG_SPOP_SBC_1	213:217	Mutation rewiring degron network	0.1667
p.S328N	ACH-001353	Pancreatic Cancer	CCLE	PETPLYT	DEG_SCF_FBW7_1	318:324	Mutation rewiring degron network	0.2222

Kaplan plot for RFX1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RFX1

UniProt ID: P22670

Entrez ID: 5989

Protein name: MHC class II regulatory factor RFX1 (Enhancer factor C) (EF-C) (Regulatory factor X 1) (RFX) (Transcription factor RFX1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RFX1 in