DegronMD

Uniprot ID: P22670

Source protein: MHC class II regulatory factor RFX1

Source gene: RFX1

Class: DEG_SCF_FBW7_1

Location: 341:347

E3 ligase: FBXW7

DEGRON score: 0.9956

ASA_SCORE: 74.8143

COIL: 0.86

CONS_SCORE: 0.3263

DSS_SCORE: 0.3825

HELIX: 0.037

FCONS_SCORE: 1.1179

RIG_SCORE: 0.7466

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P357H	TCGA-DA-A1IB	SKCM	TCGA	VSTPATS	DEG_SCF_FBW7_1	0.0556
p.P357H	DO38033	SKCM	ICGC	VSTPATS	DEG_SCF_FBW7_1	0.0556
p.T337A	TCGA-DI-A1BU	UCEC	TCGA	VSTPATS	DEG_SCF_FBW7_1	0.2222
p.T337A	DO42023	UCEC	ICGC	VSTPATS	DEG_SCF_FBW7_1	0.2222
p.G336C	DO230326	COCA	ICGC	VSTPATS	DEG_SCF_FBW7_1	0.1944
p.A349E	DO229028	LICA	ICGC	VSTPATS	DEG_SCF_FBW7_1	0.2778
p.T337K	DO229028	LICA	ICGC	VSTPATS	DEG_SCF_FBW7_1	0.2222
p.Q348K	DO50687	ORCA	ICGC	VSTPATS	DEG_SCF_FBW7_1	0.3056
p.A351V	DO229224	THCA	ICGC	VSTPATS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P22670	MHC class II regulatory factor RFX1	DEG_SCF_FBW7_1	341:347	VSTPATS	FBXW7	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons