DegronMD

Uniprot ID: P22670

Source protein: MHC class II regulatory factor RFX1

Source gene: RFX1

Class: DEG_SPOP_SBC_1

Location: 366:370

E3 ligase: SPOP

DEGRON score: 0.601

ASA_SCORE: 64.78

COIL: 0.618

CONS_SCORE: 0.2889

DSS_SCORE: 0.4347

HELIX: 0.0702

FCONS_SCORE: 1.0373

RIG_SCORE: 0.7025

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V360L	TCGA-CZ-4859	KIRC	TCGA	VASST	DEG_SPOP_SBC_1	0.1667
p.V360L	DO18602	KIRC	ICGC	VASST	DEG_SPOP_SBC_1	0.1667
p.P357H	TCGA-DA-A1IB	SKCM	TCGA	VASST	DEG_SPOP_SBC_1	0.0833
p.P357H	DO38033	SKCM	ICGC	VASST	DEG_SPOP_SBC_1	0.0833
p.T370A	DO48362	BLCA	ICGC	VASST	DEG_SPOP_SBC_1	0.7139
p.T370A	DO228483	BRCA	ICGC	VASST	DEG_SPOP_SBC_1	0.7139
p.T370A	DO229013	COCA	ICGC	VASST	DEG_SPOP_SBC_1	0.7139
p.T370A	DO229016	COCA	ICGC	VASST	DEG_SPOP_SBC_1	0.7139
p.T370A	DO229003	COCA	ICGC	VASST	DEG_SPOP_SBC_1	0.7139
p.T370A	DO229005	COCA	ICGC	VASST	DEG_SPOP_SBC_1	0.7139
p.T370A	DO230529	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	0.7139
p.T370A	DO230931	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	0.7139
p.T370A	DO231049	LUSC	ICGC	VASST	DEG_SPOP_SBC_1	0.7139
p.M358I	DO3614	BRCA	ICGC	VASST	DEG_SPOP_SBC_1	0.1111
p.S369F	DO222683	MELA	ICGC	VASST	DEG_SPOP_SBC_1	0.7982
p.G362C	DO232846	NACA	ICGC	VASST	DEG_SPOP_SBC_1	0.2222
p.S377R	DO229218	THCA	ICGC	VASST	DEG_SPOP_SBC_1	0.1389
p.S361F	DO229250	THCA	ICGC	VASST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	208:212	VASST	SPOP	0.6543	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	34:38	VASST	SPOP	0.9984	More...
P22670	MHC class II regulatory factor RFX1	DEG_SPOP_SBC_1	366:370	VASST	SPOP	0.601	More...
P35789	Zinc finger protein 93	DEG_SPOP_SBC_1	435:439	VASST	SPOP	0.6657	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	444:448	VASST	SPOP	0.937	More...
Q14008	Cytoskeleton-associated protein 5	DEG_SPOP_SBC_1	1971:1975	VASST	SPOP	0.9917	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	860:864	VASST	SPOP	0.9989	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	110:114	VASST	SPOP	0.9912	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	862:866	VASST	SPOP	0.9864	More...
Q9H4H8	Protein FAM83D	DEG_SPOP_SBC_1	487:491	VASST	SPOP	0.9868	More...
Q9UHD8	Septin-9	DEG_SPOP_SBC_1	56:60	VASST	SPOP	0.9944	More...
Q9UI36	Dachshund homolog 1	DEG_SPOP_SBC_1	128:132	VASST	SPOP	0.9985	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	2007:2011	VASST	SPOP	0.9246	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SPOP_SBC_1	1380:1384	VASST	SPOP	0.9098	More...
Q8NCQ7	Protein PROCA1	DEG_SPOP_SBC_1	46:50	VASST	SPOP	0.8048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons