DegronMD

Uniprot ID: Q8NCQ7

Source protein: Protein PROCA1

Source gene: PROCA1

Class: DEG_SPOP_SBC_1

Location: 46:50

E3 ligase: SPOP

DEGRON score: 0.8048

ASA_SCORE: 49.5

COIL: 0.7432

CONS_SCORE: 0.4937

DSS_SCORE: 0.3938

HELIX: 0.0912

FCONS_SCORE: 0.867

RIG_SCORE: 0.6863

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A55T	TCGA-06-5416	GBM	TCGA	VASST	DEG_SPOP_SBC_1	0.1944
p.A55T	TCGA-DU-6392	LGG	TCGA	VASST	DEG_SPOP_SBC_1	0.1944
p.A55T	TCGA-N7-A4Y0	UCS	TCGA	VASST	DEG_SPOP_SBC_1	0.1944
p.A55T	SIDM00789	Colorectal Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	0.1944
p.A55T	HCT-15	large_intestine	COSMIC	VASST	DEG_SPOP_SBC_1	0.1944
p.D37H	TCGA-V5-A7RE	ESCA	TCGA	VASST	DEG_SPOP_SBC_1	0.0833
p.C42Y	DO233276	GACA	ICGC	VASST	DEG_SPOP_SBC_1	0.2222
p.A57T	DO10880	GBM	ICGC	VASST	DEG_SPOP_SBC_1	0.1389
p.A57T	DO22237	LGG	ICGC	VASST	DEG_SPOP_SBC_1	0.1389
p.H45Q	DO229041	LICA	ICGC	VASST	DEG_SPOP_SBC_1	0.3056
p.Q45H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	VASST	DEG_SPOP_SBC_1	0.3056
p.Q45H	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	VASST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94876	Transmembrane and coiled-coil domains protein 1	DEG_SPOP_SBC_1	208:212	VASST	SPOP	0.6543	More...
P10071	Transcriptional activator GLI3	DEG_SPOP_SBC_1	34:38	VASST	SPOP	0.9984	More...
P22670	MHC class II regulatory factor RFX1	DEG_SPOP_SBC_1	366:370	VASST	SPOP	0.601	More...
P35789	Zinc finger protein 93	DEG_SPOP_SBC_1	435:439	VASST	SPOP	0.6657	More...
P52594	Arf-GAP domain and FG repeat-containing protein 1	DEG_SPOP_SBC_1	444:448	VASST	SPOP	0.937	More...
Q14008	Cytoskeleton-associated protein 5	DEG_SPOP_SBC_1	1971:1975	VASST	SPOP	0.9917	More...
Q7RTP6	[F-actin]-monooxygenase MICAL3	DEG_SPOP_SBC_1	860:864	VASST	SPOP	0.9989	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	110:114	VASST	SPOP	0.9912	More...
Q9H2X6	Homeodomain-interacting protein kinase 2	DEG_SPOP_SBC_1	862:866	VASST	SPOP	0.9864	More...
Q9H4H8	Protein FAM83D	DEG_SPOP_SBC_1	487:491	VASST	SPOP	0.9868	More...
Q9UHD8	Septin-9	DEG_SPOP_SBC_1	56:60	VASST	SPOP	0.9944	More...
Q9UI36	Dachshund homolog 1	DEG_SPOP_SBC_1	128:132	VASST	SPOP	0.9985	More...
Q9Y3S1	Serine/threonine-protein kinase WNK2	DEG_SPOP_SBC_1	2007:2011	VASST	SPOP	0.9246	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SPOP_SBC_1	1380:1384	VASST	SPOP	0.9098	More...
Q8NCQ7	Protein PROCA1	DEG_SPOP_SBC_1	46:50	VASST	SPOP	0.8048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons