DegronMD - Q96F05(C11orf24)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T181I	TCGA-06-0152	GBM	TCGA	APTST	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.0833
p.T181I	DO11238	GBM	ICGC	APTST	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.0833
p.A111V	TCGA-12-0778	GBM	TCGA	VASST	DEG_SPOP_SBC_1	110:114	Mutation altering degron motif	0.5825
p.A111V	DO11411	GBM	ICGC	VASST	DEG_SPOP_SBC_1	110:114	Mutation altering degron motif	0.5825
p.S365P	TCGA-12-1088	GBM	TCGA	PTPRSS	DEG_SCF_FBW7_1	360:365	Mutation altering degron motif	0.6752
p.S365P	DO13701	GBM	ICGC	PTPRSS	DEG_SCF_FBW7_1	360:365	Mutation altering degron motif	0.6752
p.A111S	TCGA-55-6970	LUAD	TCGA	VASST	DEG_SPOP_SBC_1	110:114	Mutation altering degron motif	0.6477
p.A111S	DO24421	LUAD	ICGC	VASST	DEG_SPOP_SBC_1	110:114	Mutation altering degron motif	0.6477
p.A168T	TCGA-AA-3864	COAD	TCGA	APTST	DEG_SPOP_SBC_1	168:172	Mutation altering degron motif	0.7139
p.A168T	TCGA-CG-5721	STAD	TCGA	APTST	DEG_SPOP_SBC_1	168:172	Mutation altering degron motif	0.7139
p.A168T	DO8490	COAD	ICGC	APTST	DEG_SPOP_SBC_1	168:172	Mutation altering degron motif	0.7139
p.A168T	DO38192	STAD	ICGC	APTST	DEG_SPOP_SBC_1	168:172	Mutation altering degron motif	0.7139
p.A116V	TCGA-AD-A5EJ	COAD	TCGA	VASST	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.2778
p.A116V	TCGA-XF-A9T8	BLCA	TCGA	VASST	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.2778
p.A116V	DO51927	BLCA	ICGC	VASST	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.2778
p.A116V	DO50090	COAD	ICGC	VASST	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.2778
p.T141I	TCGA-AX-A2HD	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.3056
p.T141I	DO42608	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.3056
p.P147H	TCGA-B5-A1MR	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1389
p.P147H	TCGA-B5-A1MR	UCEC	TCGA	AASST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.0833
p.P147H	DO41758	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1389
p.P147H	DO41758	UCEC	ICGC	AASST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.0833
p.A129T	TCGA-B6-A1KN	BRCA	TCGA	AASST	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1389
p.A129T	DO3656	BRCA	ICGC	AASST	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1389
p.T177I	TCGA-BP-5009	KIRC	TCGA	APTST	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.1944
p.T177I	DO18512	KIRC	ICGC	APTST	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.1944
p.A211V	TCGA-DD-AADL	LIHC	TCGA	ANTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.0556
p.A211V	TCGA-EE-A20C	SKCM	TCGA	ANTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.0556
p.A211V	DO52237	LIHC	ICGC	ANTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.0556
p.A211V	DO47665	SKCM	ICGC	ANTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.0556
p.A211S	TCGA-DD-AADL	LIHC	TCGA	ANTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.0556
p.A211S	DO52237	LIHC	ICGC	ANTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.0556
p.R213H	TCGA-EO-A3AZ	UCEC	TCGA	ANTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1111
p.R213H	DO233855	GACA	ICGC	ANTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1111
p.R213H	DO50078	UCEC	ICGC	ANTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1111
p.S159N	TCGA-F7-A624	HNSC	TCGA	AASST	DEG_SPOP_SBC_1	156:160	Mutation altering degron motif	0.7069
p.S159N	DO44440	HNSC	ICGC	AASST	DEG_SPOP_SBC_1	156:160	Mutation altering degron motif	0.7069
p.R230C	TCGA-FD-A3SO	BLCA	TCGA	ANTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1944
p.R230C	DO569	BLCA	ICGC	ANTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1944
p.M126I	TCGA-G2-AA3C	BLCA	TCGA	AASST	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0556
p.M126I	DO51883	BLCA	ICGC	AASST	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0556
p.D374V	TCGA-L9-A8F4	LUAD	TCGA	PTPRSS	DEG_SCF_FBW7_1	360:365	Mutation rewiring degron network	0.0833
p.D374V	DO49876	LUAD	ICGC	PTPRSS	DEG_SCF_FBW7_1	360:365	Mutation rewiring degron network	0.0833
p.M154V	TCGA-LN-A49W	ESCA	TCGA	AASST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.2778
p.S228R	TCGA-X6-A7WB	SARC	TCGA	ANTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.25
p.S228R	DO220314	SARC	ICGC	ANTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.25
p.R363G	DO5745	BRCA	ICGC	PTPRSS	DEG_SCF_FBW7_1	360:365	Mutation altering degron motif	0.6457
p.A122V	DO227987	COCA	ICGC	VASST	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.1111
p.A122V	SIDM01619	Endometrial Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.1111
p.A150T	DO229010	COCA	ICGC	AASST	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0556
p.A150T	DO229010	COCA	ICGC	AASST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1667
p.A150T	DO229013	COCA	ICGC	AASST	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0556
p.A150T	DO229013	COCA	ICGC	AASST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1667
p.A150T	DO229016	COCA	ICGC	AASST	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0556
p.A150T	DO229016	COCA	ICGC	AASST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1667
p.A150T	DO229003	COCA	ICGC	AASST	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0556
p.A150T	DO229003	COCA	ICGC	AASST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.1667
p.T160S	DO234378	ESAD	ICGC	AASST	DEG_SPOP_SBC_1	156:160	Mutation altering degron motif	0.6005
p.P178L	DO234459	ESAD	ICGC	APTST	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.1667
p.A168V	DO228542	GACA	ICGC	APTST	DEG_SPOP_SBC_1	168:172	Mutation altering degron motif	0.5825
p.A117V	DO233941	GACA	ICGC	VASST	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.25
p.R176Q	DO233903	GACA	ICGC	APTST	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2222
p.A106D	DO229037	LICA	ICGC	VASST	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.2222
p.T141N	DO229045	LICA	ICGC	AASST	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.3056
p.S113I	DO50672	ORCA	ICGC	VASST	DEG_SPOP_SBC_1	110:114	Mutation altering degron motif	0.7341
p.S113I	SIDM00251	Gastric Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	110:114	Mutation altering degron motif	0.7341
p.S113I	ACH-000949	Gastric Cancer	CCLE	VASST	DEG_SPOP_SBC_1	110:114	Mutation altering degron motif	0.7341
p.N222S	DO46591	OV	ICGC	ANTSS	DEG_SPOP_SBC_1	221:225	Mutation altering degron motif	0.5958
p.P178Q	DO227714	PBCA	ICGC	APTST	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.1667
p.T174A	DO51122	PRAD	ICGC	APTST	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2778
p.T177P	DO229510	SKCA	ICGC	APTST	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.1944
p.S375L	SIDM02021	Esophageal Carcinoma	GDSC	PTPRSS	DEG_SCF_FBW7_1	360:365	Mutation rewiring degron network	0.0556
p.S375L	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPRSS	DEG_SCF_FBW7_1	360:365	Mutation rewiring degron network	0.0556
p.S375L	ACH-002253	Lymphoma	CCLE	PTPRSS	DEG_SCF_FBW7_1	360:365	Mutation rewiring degron network	0.0556
p.G175R	SIDM00798	Rhabdomyosarcoma	GDSC	APTST	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.25
p.G175R	ACH-000201	Rhabdoid	CCLE	APTST	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.25
p.R213L	SIDM00232	Kidney Carcinoma	GDSC	ANTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1111
p.R213L	ACH-002168	Kidney Cancer	CCLE	ANTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1111
p.T103I	SIDM01090	Colorectal Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.1389
p.T103I	ACH-000943	Colon/Colorectal Cancer	CCLE	VASST	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.1389
p.P133L	SIDM00113	Kidney Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.25
p.S131T	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	AASST	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1944
p.S131T	ACH-000697	Lymphoma	CCLE	AASST	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1944
p.T361I	SIDM01126	Small Cell Lung Carcinoma	GDSC	PTPRSS	DEG_SCF_FBW7_1	360:365	Mutation altering degron motif	0.7078
p.T361I	SIDM00257	Neuroblastoma	GDSC	PTPRSS	DEG_SCF_FBW7_1	360:365	Mutation altering degron motif	0.7078
p.T361I	SIDM01752	Pancreatic Carcinoma	GDSC	PTPRSS	DEG_SCF_FBW7_1	360:365	Mutation altering degron motif	0.7078
p.R176W	SIDM00889	Cervical Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2222
p.R176W	SIDM01010	T-Cell Non-Hodgkin's Lymphoma	GDSC	APTST	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2222
p.R176W	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2222
p.D100H	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	VASST	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.0556
p.D100H	ACH-000892	Lung Cancer	CCLE	VASST	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.0556
p.I119S	SIDM01060	Melanoma	GDSC	VASST	DEG_SPOP_SBC_1	110:114	Mutation rewiring degron network	0.1944
p.A136S	SIDM00910	Neuroblastoma	GDSC	AASST	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7588
p.A136S	ACH-000120	Neuroblastoma	CCLE	AASST	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7588
p.A146V	SIDM00826	Colorectal Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1667
p.A146V	SIDM00826	Colorectal Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.0556
p.A146V	SIDM00823	Colorectal Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1667
p.A146V	SIDM00823	Colorectal Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	156:160	Mutation rewiring degron network	0.0556
p.A156V	SIDM00217	Colorectal Carcinoma	GDSC	AASST	DEG_SPOP_SBC_1	156:160	Mutation altering degron motif	0.5825
p.A156V	ACH-000999	Colon/Colorectal Cancer	CCLE	AASST	DEG_SPOP_SBC_1	156:160	Mutation altering degron motif	0.5825
p.P233S	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	ANTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1111
p.P233S	ACH-000282	Lung Cancer	CCLE	ANTSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1111
p.S364N	ACH-000338	Lymphoma	CCLE	PTPRSS	DEG_SCF_FBW7_1	360:365	Mutation altering degron motif	0.5958
p.S364C	ACH-000338	Lymphoma	CCLE	PTPRSS	DEG_SCF_FBW7_1	360:365	Mutation altering degron motif	0.643

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C11orf24

UniProt ID: Q96F05

Entrez ID: 53838

Protein name: Uncharacterized protein C11orf24 (Protein DM4E3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C11orf24 in