DegronMD

Uniprot ID: Q96F05

Source protein: Uncharacterized protein C11orf24

Source gene: C11orf24

Class: DEG_SPOP_SBC_1

Location: 221:225

E3 ligase: SPOP

DEGRON score: 0.9963

ASA_SCORE: 87.96

COIL: 0.9488

CONS_SCORE: 0.3628

DSS_SCORE: 0.7003

HELIX: 0.0242

FCONS_SCORE: 1.0794

RIG_SCORE: 0.6257

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A211V	TCGA-DD-AADL	LIHC	TCGA	ANTSS	DEG_SPOP_SBC_1	0.0556
p.A211V	TCGA-EE-A20C	SKCM	TCGA	ANTSS	DEG_SPOP_SBC_1	0.0556
p.A211V	DO52237	LIHC	ICGC	ANTSS	DEG_SPOP_SBC_1	0.0556
p.A211V	DO47665	SKCM	ICGC	ANTSS	DEG_SPOP_SBC_1	0.0556
p.A211S	TCGA-DD-AADL	LIHC	TCGA	ANTSS	DEG_SPOP_SBC_1	0.0556
p.A211S	DO52237	LIHC	ICGC	ANTSS	DEG_SPOP_SBC_1	0.0556
p.R213H	TCGA-EO-A3AZ	UCEC	TCGA	ANTSS	DEG_SPOP_SBC_1	0.1111
p.R213H	DO233855	GACA	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1111
p.R213H	DO50078	UCEC	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1111
p.R230C	TCGA-FD-A3SO	BLCA	TCGA	ANTSS	DEG_SPOP_SBC_1	0.1944
p.R230C	DO569	BLCA	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1944
p.S228R	TCGA-X6-A7WB	SARC	TCGA	ANTSS	DEG_SPOP_SBC_1	0.25
p.S228R	DO220314	SARC	ICGC	ANTSS	DEG_SPOP_SBC_1	0.25
p.N222S	DO46591	OV	ICGC	ANTSS	DEG_SPOP_SBC_1	0.5958
p.R213L	SIDM00232	Kidney Carcinoma	GDSC	ANTSS	DEG_SPOP_SBC_1	0.1111
p.R213L	ACH-002168	Kidney Cancer	CCLE	ANTSS	DEG_SPOP_SBC_1	0.1111
p.P233S	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	ANTSS	DEG_SPOP_SBC_1	0.1111
p.P233S	ACH-000282	Lung Cancer	CCLE	ANTSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	DEG_SPOP_SBC_1	433:437	ANTSS	SPOP	0.9984	More...
O60281	Zinc finger protein 292	DEG_SPOP_SBC_1	2504:2508	ANTSS	SPOP	0.6378	More...
P34910	Protein EVI2B	DEG_SPOP_SBC_1	113:117	ANTSS	SPOP	0.7132	More...
Q7L4P6	BEN domain-containing protein 5	DEG_SPOP_SBC_1	276:280	ANTSS	SPOP	0.9905	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	221:225	ANTSS	SPOP	0.9963	More...
Q9H694	Protein bicaudal C homolog 1	DEG_SPOP_SBC_1	503:507	ANTSS	SPOP	0.7982	More...
Q9Y2F9	BTB/POZ domain-containing protein 3	DEG_SPOP_SBC_1	33:37	ANTSS	SPOP	0.7292	More...
Q2VWP7	Protogenin	DEG_SPOP_SBC_1	732:736	ANTSS	SPOP	0.8547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons