DegronMD

Uniprot ID: O43683

Source protein: Mitotic checkpoint serine/threonine-protein kinase BUB1

Source gene: BUB1

Class: DEG_SPOP_SBC_1

Location: 433:437

E3 ligase: SPOP

DEGRON score: 0.9984

ASA_SCORE: 77.72

COIL: 0.8492

CONS_SCORE: 0.2512

DSS_SCORE: 0.5145

HELIX: 0.112

FCONS_SCORE: 0.8703

RIG_SCORE: 0.6641

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S437Y	TCGA-AA-A00N	COAD	TCGA	ANTSS	DEG_SPOP_SBC_1	0.8231
p.S437Y	TCGA-BS-A0UF	UCEC	TCGA	ANTSS	DEG_SPOP_SBC_1	0.8231
p.S437Y	TCGA-EO-A3B0	UCEC	TCGA	ANTSS	DEG_SPOP_SBC_1	0.8231
p.S437Y	DO9876	COAD	ICGC	ANTSS	DEG_SPOP_SBC_1	0.8231
p.S437Y	DO219773	UCEC	ICGC	ANTSS	DEG_SPOP_SBC_1	0.8231
p.S437Y	DO41488	UCEC	ICGC	ANTSS	DEG_SPOP_SBC_1	0.8231
p.K431N	TCGA-EE-A2GT	SKCM	TCGA	ANTSS	DEG_SPOP_SBC_1	0.2778
p.K431N	DO37946	SKCM	ICGC	ANTSS	DEG_SPOP_SBC_1	0.2778
p.G426A	TCGA-NC-A5HF	LUSC	TCGA	ANTSS	DEG_SPOP_SBC_1	0.1389
p.G426A	DO219185	LUSC	ICGC	ANTSS	DEG_SPOP_SBC_1	0.1389
p.F438C	DO49661	LIAD	ICGC	ANTSS	DEG_SPOP_SBC_1	0.3056
p.F438C	DO22830	LICA	ICGC	ANTSS	DEG_SPOP_SBC_1	0.3056
p.T441P	SIDM00534	Colorectal Carcinoma	GDSC	ANTSS	DEG_SPOP_SBC_1	0.6667
p.T441P	ACH-000986	Colon/Colorectal Cancer	CCLE	ANTSS	DEG_SPOP_SBC_1	0.6667
p.T441P	HT-115	large_intestine	COSMIC	ANTSS	DEG_SPOP_SBC_1	0.6667
p.V442M	22RV1	prostate	COSMIC	ANTSS	DEG_SPOP_SBC_1	0.1944
p.P440H	NB10	autonomic_ganglia	COSMIC	ANTSS	DEG_SPOP_SBC_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	DEG_SPOP_SBC_1	433:437	ANTSS	SPOP	0.9984	More...
O60281	Zinc finger protein 292	DEG_SPOP_SBC_1	2504:2508	ANTSS	SPOP	0.6378	More...
P34910	Protein EVI2B	DEG_SPOP_SBC_1	113:117	ANTSS	SPOP	0.7132	More...
Q7L4P6	BEN domain-containing protein 5	DEG_SPOP_SBC_1	276:280	ANTSS	SPOP	0.9905	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SPOP_SBC_1	221:225	ANTSS	SPOP	0.9963	More...
Q9H694	Protein bicaudal C homolog 1	DEG_SPOP_SBC_1	503:507	ANTSS	SPOP	0.7982	More...
Q9Y2F9	BTB/POZ domain-containing protein 3	DEG_SPOP_SBC_1	33:37	ANTSS	SPOP	0.7292	More...
Q2VWP7	Protogenin	DEG_SPOP_SBC_1	732:736	ANTSS	SPOP	0.8547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons