DegronMD - O60281(ZNF292)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1189S	TCGA-92-8065	LUSC	TCGA	VSTPLLS	DEG_SCF_FBW7_1	1199:1205	Mutation rewiring degron network	0.0556
p.P1189S	DO27074	LUSC	ICGC	VSTPLLS	DEG_SCF_FBW7_1	1199:1205	Mutation rewiring degron network	0.0556
p.V647A	TCGA-A5-A0G2	UCEC	TCGA	FIVFND	LIG_APCC_ABBA_1	645:650	Mutation altering degron motif	0.6936
p.V647A	DO41235	UCEC	ICGC	FIVFND	LIG_APCC_ABBA_1	645:650	Mutation altering degron motif	0.6936
p.P1064H	TCGA-A5-A0G2	UCEC	TCGA	VKTSS	DEG_SPOP_SBC_1	1054:1058	Mutation rewiring degron network	0.1667
p.K1066E	TCGA-AA-3663	COAD	TCGA	VKTSS	DEG_SPOP_SBC_1	1054:1058	Mutation substituting flanking lysine	0.2222
p.K1066E	DO9346	COAD	ICGC	VKTSS	DEG_SPOP_SBC_1	1054:1058	Mutation substituting flanking lysine	0.2222
p.K1066E	DO222503	COCA	ICGC	VKTSS	DEG_SPOP_SBC_1	1054:1058	Mutation substituting flanking lysine	0.2222
p.T1067I	TCGA-AP-A051	UCEC	TCGA	VKTSS	DEG_SPOP_SBC_1	1054:1058	Mutation rewiring degron network	0.0833
p.T1067I	DO42673	UCEC	ICGC	VKTSS	DEG_SPOP_SBC_1	1054:1058	Mutation rewiring degron network	0.0833
p.T1870A	TCGA-AX-A1CE	UCEC	TCGA	LTPTPVKS	DEG_SCF_FBW7_1	1869:1876	Mutation altering degron motif	0.6028
p.T1870A	DO42280	UCEC	ICGC	LTPTPVKS	DEG_SCF_FBW7_1	1869:1876	Mutation altering degron motif	0.6028
p.H1195Y	TCGA-BF-A5ES	SKCM	TCGA	VSTPLLS	DEG_SCF_FBW7_1	1199:1205	Mutation rewiring degron network	0.2222
p.L1065I	TCGA-BS-A0UV	UCEC	TCGA	VKTSS	DEG_SPOP_SBC_1	1054:1058	Mutation rewiring degron network	0.1389
p.Y641C	TCGA-CD-8531	STAD	TCGA	FIVFND	LIG_APCC_ABBA_1	645:650	Mutation blocking phosphorylation signal	0.6667
p.Q2515H	TCGA-D3-A2JC	SKCM	TCGA	ANTSS	DEG_SPOP_SBC_1	2504:2508	Mutation rewiring degron network	0.1389
p.I1211V	TCGA-DM-A28F	COAD	TCGA	VSTPLLS	DEG_SCF_FBW7_1	1199:1205	Mutation rewiring degron network	0.1667
p.I1211V	DO9828	COAD	ICGC	VSTPLLS	DEG_SCF_FBW7_1	1199:1205	Mutation rewiring degron network	0.1667
p.D655N	TCGA-EO-A22U	UCEC	TCGA	FIVFND	LIG_APCC_ABBA_1	645:650	Mutation rewiring degron network	0.1944
p.D655N	DO43755	UCEC	ICGC	FIVFND	LIG_APCC_ABBA_1	645:650	Mutation rewiring degron network	0.1944
p.L1060I	TCGA-EO-A3AY	UCEC	TCGA	VKTSS	DEG_SPOP_SBC_1	1054:1058	Mutation rewiring degron network	0.2778
p.L1060I	DO42793	UCEC	ICGC	VKTSS	DEG_SPOP_SBC_1	1054:1058	Mutation rewiring degron network	0.2778
p.P1873H	TCGA-EY-A215	UCEC	TCGA	LTPTPVKS	DEG_SCF_FBW7_1	1869:1876	Mutation altering degron motif	0.7694
p.N1059S	TCGA-F7-A623	HNSC	TCGA	VKTSS	DEG_SPOP_SBC_1	1054:1058	Mutation rewiring degron network	0.3056
p.N1293S	TCGA-L5-A8NI	ESCA	TCGA	DSGTNS	DEG_SCF_TRCP1_1	1280:1285	Mutation rewiring degron network	0.1111
p.E1883Q	DO218976	BLCA	ICGC	LTPTPVKS	DEG_SCF_FBW7_1	1869:1876	Mutation rewiring degron network	0.1389
p.E1291G	DO233888	GACA	ICGC	DSGTNS	DEG_SCF_TRCP1_1	1280:1285	Mutation rewiring degron network	0.1667
p.N1054S	DO44443	HNSC	ICGC	VKTSS	DEG_SPOP_SBC_1	1054:1058	Mutation altering degron motif	0.7069
p.A1067P	DO22388	LGG	ICGC	VKTSS	DEG_SPOP_SBC_1	1054:1058	Mutation rewiring degron network	0.0833
p.D651Y	DO228952	LICA	ICGC	FIVFND	LIG_APCC_ABBA_1	645:650	Mutation rewiring degron network	0.3056
p.Q1295H	DO229025	LICA	ICGC	DSGTNS	DEG_SCF_TRCP1_1	1280:1285	Mutation rewiring degron network	0.0556
p.A2499S	DO229036	LICA	ICGC	ANTSS	DEG_SPOP_SBC_1	2504:2508	Mutation rewiring degron network	0.1944
p.D654Y	DO229045	LICA	ICGC	FIVFND	LIG_APCC_ABBA_1	645:650	Mutation blocking phosphorylation signal	0.6667
p.S2511G	DO231681	LINC	ICGC	ANTSS	DEG_SPOP_SBC_1	2504:2508	Mutation rewiring degron network	0.25
p.N1295S	DO50800	LIRI	ICGC	DSGTNS	DEG_SCF_TRCP1_1	1280:1285	Mutation rewiring degron network	0.0556
p.N2494S	DO229293	LMS	ICGC	ANTSS	DEG_SPOP_SBC_1	2504:2508	Mutation rewiring degron network	0.0556
p.S1046F	DO222402	MELA	ICGC	VKTSS	DEG_SPOP_SBC_1	1054:1058	Mutation rewiring degron network	0.1111
p.S1882F	DO47480	SKCM	ICGC	LTPTPVKS	DEG_SCF_FBW7_1	1869:1876	Mutation rewiring degron network	0.1667
p.Q2510H	DO47578	SKCM	ICGC	ANTSS	DEG_SPOP_SBC_1	2504:2508	Mutation rewiring degron network	0.2778
p.H1190Y	DO219456	SKCM	ICGC	VSTPLLS	DEG_SCF_FBW7_1	1199:1205	Mutation rewiring degron network	0.0833
p.Y636C	DO47877	STAD	ICGC	FIVFND	LIG_APCC_ABBA_1	645:650	Mutation substituting flanking lysine	0.1944
p.S1212Y	DO50076	UCEC	ICGC	VSTPLLS	DEG_SCF_FBW7_1	1199:1205	Mutation rewiring degron network	0.1389
p.L1055I	DO43202	UCEC	ICGC	VKTSS	DEG_SPOP_SBC_1	1054:1058	Mutation altering degron motif	0.7174
p.H1291Q	DO41542	UCEC	ICGC	DSGTNS	DEG_SCF_TRCP1_1	1280:1285	Mutation rewiring degron network	0.1667
p.P1059H	DO41235	UCEC	ICGC	VKTSS	DEG_SPOP_SBC_1	1054:1058	Mutation rewiring degron network	0.3056
p.P1868H	DO42665	UCEC	ICGC	LTPTPVKS	DEG_SCF_FBW7_1	1869:1876	Mutation rewiring degron network	0.3056
p.E1291V	SIDM01944	Esophageal Carcinoma	GDSC	DSGTNS	DEG_SCF_TRCP1_1	1280:1285	Mutation rewiring degron network	0.1667
p.S1270T	SIDM01282	Colorectal Carcinoma	GDSC	DSGTNS	DEG_SCF_TRCP1_1	1280:1285	Mutation rewiring degron network	0.0556
p.F1287L	SIDM00447	B-Lymphoblastic Leukemia	GDSC	DSGTNS	DEG_SCF_TRCP1_1	1280:1285	Mutation rewiring degron network	0.2778
p.F1287L	ACH-000960	Leukemia	CCLE	DSGTNS	DEG_SCF_TRCP1_1	1280:1285	Mutation rewiring degron network	0.2778
p.F1287L	REH	haematopoietic and lymphoid tissue	COSMIC	DSGTNS	DEG_SCF_TRCP1_1	1280:1285	Mutation rewiring degron network	0.2778
p.F645V	SIDM00193	Colorectal Carcinoma	GDSC	FIVFND	LIG_APCC_ABBA_1	645:650	Mutation altering degron motif	0.5957
p.F645V	ACH-000991	Colon/Colorectal Cancer	CCLE	FIVFND	LIG_APCC_ABBA_1	645:650	Mutation altering degron motif	0.5957
p.F645V	SNU-81	large intestine	COSMIC	FIVFND	LIG_APCC_ABBA_1	645:650	Mutation altering degron motif	0.5957
p.V1874D	SIDM00057	Neuroblastoma	GDSC	LTPTPVKS	DEG_SCF_FBW7_1	1869:1876	Mutation altering degron motif	0.6674
p.V1874D	SIDM00552	Rhabdomyosarcoma	GDSC	LTPTPVKS	DEG_SCF_FBW7_1	1869:1876	Mutation altering degron motif	0.6674
p.V1874D	ACH-000607	Rhabdoid	CCLE	LTPTPVKS	DEG_SCF_FBW7_1	1869:1876	Mutation altering degron motif	0.6674
p.V1874D	KYM-1	soft tissue	COSMIC	LTPTPVKS	DEG_SCF_FBW7_1	1869:1876	Mutation altering degron motif	0.6674
p.T1201I	SIDM01218	Other Solid Cancers	GDSC	VSTPLLS	DEG_SCF_FBW7_1	1199:1205	Mutation altering degron motif	0.7078
p.T1201I	JEG-3	placenta	COSMIC	VSTPLLS	DEG_SCF_FBW7_1	1199:1205	Mutation altering degron motif	0.7078
p.T1870I	SIDM00516	Melanoma	GDSC	LTPTPVKS	DEG_SCF_FBW7_1	1869:1876	Mutation altering degron motif	0.5966
p.T1870I	ACH-002166	Skin Cancer	CCLE	LTPTPVKS	DEG_SCF_FBW7_1	1869:1876	Mutation altering degron motif	0.5966
p.T1870I	MZ7-mel	skin	COSMIC	LTPTPVKS	DEG_SCF_FBW7_1	1869:1876	Mutation altering degron motif	0.5966
p.V1861L	SIDM01105	Melanoma	GDSC	LTPTPVKS	DEG_SCF_FBW7_1	1869:1876	Mutation rewiring degron network	0.1111
p.V1861L	ACH-000423	Skin Cancer	CCLE	LTPTPVKS	DEG_SCF_FBW7_1	1869:1876	Mutation rewiring degron network	0.1111
p.V1861L	SK-MEL-3	skin	COSMIC	LTPTPVKS	DEG_SCF_FBW7_1	1869:1876	Mutation rewiring degron network	0.1111
p.V2500I	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	ANTSS	DEG_SPOP_SBC_1	2504:2508	Mutation rewiring degron network	0.2222
p.V2500I	ACH-001498	Lymphoma	CCLE	ANTSS	DEG_SPOP_SBC_1	2504:2508	Mutation rewiring degron network	0.2222
p.V2500I	Farage	haematopoietic and lymphoid tissue	COSMIC	ANTSS	DEG_SPOP_SBC_1	2504:2508	Mutation rewiring degron network	0.2222
p.N2509K	SIDM01611	Endometrial Carcinoma	GDSC	ANTSS	DEG_SPOP_SBC_1	2504:2508	Mutation rewiring degron network	0.3056
p.N2509K	ACH-000996	Endometrial/Uterine Cancer	CCLE	ANTSS	DEG_SPOP_SBC_1	2504:2508	Mutation rewiring degron network	0.3056
p.V1869D	KYM-1	soft tissue	COSMIC	LTPTPVKS	DEG_SCF_FBW7_1	1869:1876	Mutation altering degron motif	0.7785
p.T1865I	MZ7-mel	skin	COSMIC	LTPTPVKS	DEG_SCF_FBW7_1	1869:1876	Mutation rewiring degron network	0.2222
p.L1198S	FLO-1	oesophagus	COSMIC	VSTPLLS	DEG_SCF_FBW7_1	1199:1205	Mutation rewiring degron network	0.3056
p.F1282L	REH	haematopoietic and lymphoid tissue	COSMIC	DSGTNS	DEG_SCF_TRCP1_1	1280:1285	Mutation altering degron motif	0.6981
p.T1196I	JEG-3	placenta	COSMIC	VSTPLLS	DEG_SCF_FBW7_1	1199:1205	Mutation rewiring degron network	0.25
p.L1203S	FLO-1	oesophagus	COSMIC	VSTPLLS	DEG_SCF_FBW7_1	1199:1205	Mutation altering degron motif	0.6556
p.V2495I	Farage	haematopoietic and lymphoid tissue	COSMIC	ANTSS	DEG_SPOP_SBC_1	2504:2508	Mutation rewiring degron network	0.0833
p.F640V	SNU-81	large intestine	COSMIC	FIVFND	LIG_APCC_ABBA_1	645:650	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF292

UniProt ID: O60281

Entrez ID: 23036

Protein name: Zinc finger protein 292

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF292 in