DegronMD

Uniprot ID: O60281

Source protein: Zinc finger protein 292

Source gene: ZNF292

Class: DEG_SCF_FBW7_1

Location: 1199:1205

E3 ligase: FBXW7

DEGRON score: 0.8885

ASA_SCORE: 81.7857

COIL: 0.879

CONS_SCORE: 0.527

DSS_SCORE: 0.3349

HELIX: 0.0791

FCONS_SCORE: 0.9047

RIG_SCORE: 0.7217

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1189S	TCGA-92-8065	LUSC	TCGA	VSTPLLS	DEG_SCF_FBW7_1	0.0556
p.P1189S	DO27074	LUSC	ICGC	VSTPLLS	DEG_SCF_FBW7_1	0.0556
p.H1195Y	TCGA-BF-A5ES	SKCM	TCGA	VSTPLLS	DEG_SCF_FBW7_1	0.2222
p.I1211V	TCGA-DM-A28F	COAD	TCGA	VSTPLLS	DEG_SCF_FBW7_1	0.1667
p.I1211V	DO9828	COAD	ICGC	VSTPLLS	DEG_SCF_FBW7_1	0.1667
p.H1190Y	DO219456	SKCM	ICGC	VSTPLLS	DEG_SCF_FBW7_1	0.0833
p.S1212Y	DO50076	UCEC	ICGC	VSTPLLS	DEG_SCF_FBW7_1	0.1389
p.T1201I	SIDM01218	Other Solid Cancers	GDSC	VSTPLLS	DEG_SCF_FBW7_1	0.7078
p.T1201I	JEG-3	placenta	COSMIC	VSTPLLS	DEG_SCF_FBW7_1	0.7078
p.L1198S	FLO-1	oesophagus	COSMIC	VSTPLLS	DEG_SCF_FBW7_1	0.3056
p.T1196I	JEG-3	placenta	COSMIC	VSTPLLS	DEG_SCF_FBW7_1	0.25
p.L1203S	FLO-1	oesophagus	COSMIC	VSTPLLS	DEG_SCF_FBW7_1	0.6556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60281	Zinc finger protein 292	DEG_SCF_FBW7_1	1199:1205	VSTPLLS	FBXW7	0.8885	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons