DegronMD

Uniprot ID: O60281

Source protein: Zinc finger protein 292

Source gene: ZNF292

Class: DEG_SPOP_SBC_1

Location: 1054:1058

E3 ligase: SPOP

DEGRON score: 0.9214

ASA_SCORE: 75.56

COIL: 0.7196

CONS_SCORE: 0.4327

DSS_SCORE: 0.2779

HELIX: 0.1228

FCONS_SCORE: 0.8422

RIG_SCORE: 0.7575

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1064H	TCGA-A5-A0G2	UCEC	TCGA	VKTSS	DEG_SPOP_SBC_1	0.1667
p.K1066E	TCGA-AA-3663	COAD	TCGA	VKTSS	DEG_SPOP_SBC_1	0.2222
p.K1066E	DO9346	COAD	ICGC	VKTSS	DEG_SPOP_SBC_1	0.2222
p.K1066E	DO222503	COCA	ICGC	VKTSS	DEG_SPOP_SBC_1	0.2222
p.T1067I	TCGA-AP-A051	UCEC	TCGA	VKTSS	DEG_SPOP_SBC_1	0.0833
p.T1067I	DO42673	UCEC	ICGC	VKTSS	DEG_SPOP_SBC_1	0.0833
p.L1065I	TCGA-BS-A0UV	UCEC	TCGA	VKTSS	DEG_SPOP_SBC_1	0.1389
p.L1060I	TCGA-EO-A3AY	UCEC	TCGA	VKTSS	DEG_SPOP_SBC_1	0.2778
p.L1060I	DO42793	UCEC	ICGC	VKTSS	DEG_SPOP_SBC_1	0.2778
p.N1059S	TCGA-F7-A623	HNSC	TCGA	VKTSS	DEG_SPOP_SBC_1	0.3056
p.N1054S	DO44443	HNSC	ICGC	VKTSS	DEG_SPOP_SBC_1	0.7069
p.A1067P	DO22388	LGG	ICGC	VKTSS	DEG_SPOP_SBC_1	0.0833
p.S1046F	DO222402	MELA	ICGC	VKTSS	DEG_SPOP_SBC_1	0.1111
p.L1055I	DO43202	UCEC	ICGC	VKTSS	DEG_SPOP_SBC_1	0.7174
p.P1059H	DO41235	UCEC	ICGC	VKTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60281	Zinc finger protein 292	DEG_SPOP_SBC_1	1054:1058	VKTSS	SPOP	0.9214	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1466:1470	VKTSS	SPOP	0.6301	More...
Q5XKE5	Keratin, type II cytoskeletal 79	DEG_SPOP_SBC_1	528:532	VKTSS	SPOP	0.6487	More...
Q8WUA4	General transcription factor 3C polypeptide 2	DEG_SPOP_SBC_1	36:40	VKTSS	SPOP	0.7835	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	300:304	VKTSS	SPOP	0.9861	More...
Q96L14	Cep170-like protein	DEG_SPOP_SBC_1	175:179	VKTSS	SPOP	0.8196	More...
Q9UK28	Transmembrane protein 59-like	DEG_SPOP_SBC_1	237:241	VKTSS	SPOP	0.8378	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons