DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VKTSS
Uniprot ID:
Q96L14
Source protein:
Cep170-like protein
Source gene:
CEP170P1
Class:
DEG_SPOP_SBC_1
Location:
175:179
E3 ligase:
SPOP
DEGRON score:
0.8196
ASA_SCORE:
55.04
COIL:
0.7926
CONS_SCORE:
1
DSS_SCORE:
0.2687
HELIX:
0.1084
FCONS_SCORE:
1
RIG_SCORE:
0.7684
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CEP170P1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VKTSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60281
Zinc finger protein 292
DEG_SPOP_SBC_1
1054:1058
VKTSS
SPOP
0.9214
More...
Q5SW79
Centrosomal protein of 170 kDa
DEG_SPOP_SBC_1
1466:1470
VKTSS
SPOP
0.6301
More...
Q5XKE5
Keratin, type II cytoskeletal 79
DEG_SPOP_SBC_1
528:532
VKTSS
SPOP
0.6487
More...
Q8WUA4
General transcription factor 3C polypeptide 2
DEG_SPOP_SBC_1
36:40
VKTSS
SPOP
0.7835
More...
Q8WWK9
Cytoskeleton-associated protein 2
DEG_SPOP_SBC_1
300:304
VKTSS
SPOP
0.9861
More...
Q96L14
Cep170-like protein
DEG_SPOP_SBC_1
175:179
VKTSS
SPOP
0.8196
More...
Q9UK28
Transmembrane protein 59-like
DEG_SPOP_SBC_1
237:241
VKTSS
SPOP
0.8378
More...