DegronMD

Uniprot ID: Q5SW79

Source protein: Centrosomal protein of 170 kDa

Source gene: CEP170

Class: DEG_SPOP_SBC_1

Location: 1466:1470

E3 ligase: SPOP

DEGRON score: 0.6301

ASA_SCORE: 63.62

COIL: 0.8352

CONS_SCORE: 0.6441

DSS_SCORE: 0.2687

HELIX: 0.0864

FCONS_SCORE: 0.9518

RIG_SCORE: 0.7684

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1478H	TCGA-63-A5MT	LUSC	TCGA	VKTSS	DEG_SPOP_SBC_1	0.1111
p.I1473M	TCGA-AJ-A3EL	UCEC	TCGA	VKTSS	DEG_SPOP_SBC_1	0.25
p.S1474Y	TCGA-F5-6814	READ	TCGA	VKTSS	DEG_SPOP_SBC_1	0.2222
p.S1474Y	SIDM00193	Colorectal Carcinoma	GDSC	VKTSS	DEG_SPOP_SBC_1	0.2222
p.S1474Y	ACH-000991	Colon/Colorectal Cancer	CCLE	VKTSS	DEG_SPOP_SBC_1	0.2222
p.S1474Y	SNU-81	large_intestine	COSMIC	VKTSS	DEG_SPOP_SBC_1	0.2222
p.E1460Q	TCGA-YC-A89H	BLCA	TCGA	VKTSS	DEG_SPOP_SBC_1	0.1667
p.L1480M	SIDM01218	Other Solid Cancers	GDSC	VKTSS	DEG_SPOP_SBC_1	0.0556
p.S1475F	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	VKTSS	DEG_SPOP_SBC_1	0.1944
p.S1475F	ACH-000865	Esophageal Cancer	CCLE	VKTSS	DEG_SPOP_SBC_1	0.1944
p.S1475F	KYSE-450	oesophagus	COSMIC	VKTSS	DEG_SPOP_SBC_1	0.1944
p.E1472Q	SIDM00554	Ovarian Carcinoma	GDSC	VKTSS	DEG_SPOP_SBC_1	0.2778
p.E1472Q	KURAMOCHI	ovary	COSMIC	VKTSS	DEG_SPOP_SBC_1	0.2778
p.I1468T	JHH-4	liver	COSMIC	VKTSS	DEG_SPOP_SBC_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60281	Zinc finger protein 292	DEG_SPOP_SBC_1	1054:1058	VKTSS	SPOP	0.9214	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1466:1470	VKTSS	SPOP	0.6301	More...
Q5XKE5	Keratin, type II cytoskeletal 79	DEG_SPOP_SBC_1	528:532	VKTSS	SPOP	0.6487	More...
Q8WUA4	General transcription factor 3C polypeptide 2	DEG_SPOP_SBC_1	36:40	VKTSS	SPOP	0.7835	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	300:304	VKTSS	SPOP	0.9861	More...
Q96L14	Cep170-like protein	DEG_SPOP_SBC_1	175:179	VKTSS	SPOP	0.8196	More...
Q9UK28	Transmembrane protein 59-like	DEG_SPOP_SBC_1	237:241	VKTSS	SPOP	0.8378	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons