DegronMD - Q5SW79(CEP170)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G276W	TCGA-05-4417	LUAD	TCGA	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation rewiring degron network	0.1111
p.G276W	DO23570	LUAD	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation rewiring degron network	0.1111
p.S1034C	TCGA-29-1764	OV	TCGA	DQETYSCKP	CBL_PTK	1043:1051	Mutation blocking phosphorylation signal	0.5278
p.R1164C	TCGA-44-7662	LUAD	TCGA	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation rewiring degron network	0.2778
p.S1133C	TCGA-4Z-AA7M	BLCA	TCGA	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation blocking phosphorylation signal	0.75
p.Q1478H	TCGA-63-A5MT	LUSC	TCGA	VKTSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.1111
p.A1341S	TCGA-85-7710	LUSC	TCGA	APSTT	DEG_SPOP_SBC_1	1332:1336	Mutation rewiring degron network	0.1944
p.H297Y	TCGA-A5-A0G2	UCEC	TCGA	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation rewiring degron network	0.1667
p.H297Y	DO41235	UCEC	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation rewiring degron network	0.1667
p.Q1152R	TCGA-A6-2686	COAD	TCGA	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation rewiring degron network	0.2778
p.Q1152E	TCGA-AC-A5XS	BRCA	TCGA	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation rewiring degron network	0.2778
p.R1267C	TCGA-AJ-A3BG	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.0833
p.R1267C	TCGA-NH-A6GB	COAD	TCGA	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.0833
p.I1473M	TCGA-AJ-A3EL	UCEC	TCGA	VKTSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.25
p.I1147V	TCGA-AO-A124	BRCA	TCGA	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation rewiring degron network	0.1389
p.R1054W	TCGA-AP-A051	UCEC	TCGA	DQETYSCKP	CBL_PTK	1043:1051	Mutation rewiring degron network	0.25
p.R1154L	TCGA-AP-A053	UCEC	TCGA	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation altering degron motif	0.7316
p.S1133Y	TCGA-AP-A1DV	UCEC	TCGA	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation blocking phosphorylation signal	0.75
p.S1133Y	TCGA-AX-A2HC	UCEC	TCGA	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation blocking phosphorylation signal	0.75
p.E558K	TCGA-AR-A2LE	BRCA	TCGA	PLTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.2222
p.S1172Y	TCGA-AX-A05Z	UCEC	TCGA	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation rewiring degron network	0.0556
p.S1172Y	TCGA-BS-A0UV	UCEC	TCGA	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation rewiring degron network	0.0556
p.A1119V	TCGA-AX-A0J0	UCEC	TCGA	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.0833
p.E656D	TCGA-AY-6196	COAD	TCGA	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.1389
p.R643Q	TCGA-AZ-4315	COAD	TCGA	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation altering degron motif	0.6218
p.R643Q	TCGA-C8-A131	BRCA	TCGA	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation altering degron motif	0.6218
p.D1043N	TCGA-CC-A3M9	LIHC	TCGA	DQETYSCKP	CBL_PTK	1043:1051	Mutation altering degron motif	0.5821
p.R1054Q	TCGA-CM-5349	COAD	TCGA	DQETYSCKP	CBL_PTK	1043:1051	Mutation rewiring degron network	0.25
p.S1279C	TCGA-CN-4723	HNSC	TCGA	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation altering degron motif	0.8652
p.G574S	TCGA-CQ-6223	HNSC	TCGA	PLTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.1111
p.P1344S	TCGA-D3-A8GL	SKCM	TCGA	APSTT	DEG_SPOP_SBC_1	1332:1336	Mutation rewiring degron network	0.1111
p.T1130A	TCGA-DU-6392	LGG	TCGA	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation altering degron motif	0.7139
p.D1118A	TCGA-DU-6392	LGG	TCGA	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.0556
p.L645H	TCGA-EE-A183	SKCM	TCGA	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation altering degron motif	0.7313
p.A1119D	TCGA-EJ-5518	PRAD	TCGA	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.0833
p.S576Y	TCGA-EO-A22R	UCEC	TCGA	PLTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.0556
p.R1142C	TCGA-EY-A1GI	UCEC	TCGA	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.0556
p.R1142C	SIDM00217	Colorectal Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.0556
p.R1142C	ACH-000999	Colon/Colorectal Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.0556
p.R1142C	SNU-1040	large intestine	COSMIC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.0556
p.S1474Y	TCGA-F5-6814	READ	TCGA	VKTSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.2222
p.S1474Y	SIDM00193	Colorectal Carcinoma	GDSC	VKTSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.2222
p.S1474Y	ACH-000991	Colon/Colorectal Cancer	CCLE	VKTSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.2222
p.S1474Y	SNU-81	large intestine	COSMIC	VKTSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.2222
p.R1146W	TCGA-FI-A2D5	UCEC	TCGA	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation rewiring degron network	0.1111
p.R1146W	ACH-000951	Lung Cancer	CCLE	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation rewiring degron network	0.1111
p.R1146W	NCI-H2342	lung	COSMIC	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation rewiring degron network	0.1111
p.P289T	TCGA-FS-A1ZN	SKCM	TCGA	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation altering degron motif	0.7031
p.P289T	DO38165	SKCM	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation altering degron motif	0.7031
p.P289S	TCGA-FW-A3R5	SKCM	TCGA	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation altering degron motif	0.6752
p.P289S	DO37406	SKCM	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation altering degron motif	0.6752
p.S1334N	TCGA-NG-A4VU	UCS	TCGA	APSTT	DEG_SPOP_SBC_1	1332:1336	Mutation altering degron motif	0.7069
p.E1460Q	TCGA-YC-A89H	BLCA	TCGA	VKTSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.1667
p.T640I	DO48401	BLCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.3056
p.T640I	DO228483	BRCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.3056
p.T640I	DO230334	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.3056
p.T640I	DO224661	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.3056
p.T640I	DO224761	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.3056
p.T640I	DO222864	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.3056
p.T640I	DO229010	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.3056
p.T640I	DO229013	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.3056
p.T640I	DO229016	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.3056
p.T640I	DO229005	COCA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.3056
p.T640I	DO229480	LAML	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.3056
p.T640I	DO51027	LAML	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.3056
p.S1035C	DO218976	BLCA	ICGC	DQETYSCKP	CBL_PTK	1043:1051	Mutation rewiring degron network	0.1111
p.P289Q	DO225244	BRCA	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation altering degron motif	0.7035
p.Q1054E	DO50023	BRCA	ICGC	DQETYSCKP	CBL_PTK	1043:1051	Mutation rewiring degron network	0.25
p.I1049V	DO1287	BRCA	ICGC	DQETYSCKP	CBL_PTK	1043:1051	Mutation altering degron motif	0.7076
p.R279T	DO44242	BRCA	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation rewiring degron network	0.1944
p.V565I	DO48996	CESC	ICGC	PLTTS	DEG_SPOP_SBC_1	562:566	Mutation altering degron motif	0.7076
p.E558D	DO10300	COAD	ICGC	PLTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.2222
p.Q1054R	DO7828	COAD	ICGC	DQETYSCKP	CBL_PTK	1043:1051	Mutation rewiring degron network	0.25
p.K563N	DO7828	COAD	ICGC	PLTTS	DEG_SPOP_SBC_1	562:566	Mutation altering degron motif	0.6918
p.K563N	TE-9	oesophagus	COSMIC	PLTTS	DEG_SPOP_SBC_1	562:566	Mutation altering degron motif	0.6918
p.A1126S	DO222849	COCA	ICGC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.2778
p.A1126S	DO228464	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.2778
p.A1126S	DO231075	LUSC	ICGC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.2778
p.A1126S	KU-19-19	urinary tract	COSMIC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.2778
p.A1126S	NCI-SNU-5	stomach	COSMIC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.2778
p.A1126S	SNU-1040	large intestine	COSMIC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.2778
p.A1126S	MRK-nu-1	breast	COSMIC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.2778
p.A1126S	SNU-C5	large intestine	COSMIC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.2778
p.E632Q	DO228607	GACA	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation blocking phosphorylation signal	0.5278
p.I275V	DO14250	HNSC	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation rewiring degron network	0.0833
p.F280L	DO218923	LUAD	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation rewiring degron network	0.2222
p.E286K	DO26520	LUSC	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation altering degron motif	0.7022
p.E286K	DO47727	STAD	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation altering degron motif	0.7022
p.Q655K	DO26560	LUSC	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.1667
p.Q567L	DO45449	LUSC	ICGC	PLTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.3056
p.P282L	DO220878	MELA	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation rewiring degron network	0.2778
p.T1120I	DO32576	OV	ICGC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.1111
p.K649N	DO37356	READ	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation altering degron motif	0.6918
p.A659V	DO37790	SKCM	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.0556
p.E657K	DO38439	STAD	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.1111
p.R1056L	DO43378	UCEC	ICGC	DQETYSCKP	CBL_PTK	1043:1051	Mutation rewiring degron network	0.1944
p.S1035Y	DO43186	UCEC	ICGC	DQETYSCKP	CBL_PTK	1043:1051	Mutation rewiring degron network	0.1111
p.S1035Y	DO41572	UCEC	ICGC	DQETYSCKP	CBL_PTK	1043:1051	Mutation rewiring degron network	0.1111
p.S641Y	DO52412	UCEC	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation altering degron motif	0.712
p.S641Y	DO41758	UCEC	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation altering degron motif	0.712
p.S641Y	DO41331	UCEC	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation altering degron motif	0.712
p.K633N	DO41903	UCEC	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation blocking phosphorylation signal	0.5556
p.R1044C	DO41211	UCEC	ICGC	DQETYSCKP	CBL_PTK	1043:1051	Mutation altering degron motif	0.8301
p.R1044C	SNU-1040	large intestine	COSMIC	DQETYSCKP	CBL_PTK	1043:1051	Mutation altering degron motif	0.8301
p.R1048W	DO41331	UCEC	ICGC	DQETYSCKP	CBL_PTK	1043:1051	Mutation altering degron motif	0.8634
p.R1048W	NCI-H2342	lung	COSMIC	DQETYSCKP	CBL_PTK	1043:1051	Mutation altering degron motif	0.8634
p.T636I	DO41379	UCEC	ICGC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation blocking phosphorylation signal	0.6389
p.F301V	SIDM02014	Esophageal Carcinoma	GDSC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation rewiring degron network	0.0556
p.L1268M	SIDM00845	Burkitt's Lymphoma	GDSC	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.1111
p.L1268M	SIDM00035	Thyroid Gland Carcinoma	GDSC	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.1111
p.L1268M	Daudi	haematopoietic and lymphoid tissue	COSMIC	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.1111
p.A1060T	SIDM01090	Colorectal Carcinoma	GDSC	DQETYSCKP	CBL_PTK	1043:1051	Mutation rewiring degron network	0.0833
p.A1060T	ACH-000943	Colon/Colorectal Cancer	CCLE	DQETYSCKP	CBL_PTK	1043:1051	Mutation rewiring degron network	0.0833
p.A1060T	RKO	large intestine	COSMIC	DQETYSCKP	CBL_PTK	1043:1051	Mutation rewiring degron network	0.0833
p.K1136N	SIDM00216	Colorectal Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation substituting flanking lysine	0.3333
p.K1136N	ACH-000989	Colon/Colorectal Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation substituting flanking lysine	0.3333
p.K1136N	SNU-175	large intestine	COSMIC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation substituting flanking lysine	0.3333
p.S1270N	SIDM01206	Neuroblastoma	GDSC	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation blocking phosphorylation signal	0.6111
p.S1270N	ACH-000310	Neuroblastoma	CCLE	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation blocking phosphorylation signal	0.6111
p.S1270N	ACH-002248	Neuroblastoma	CCLE	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation blocking phosphorylation signal	0.6111
p.S1270N	IMR-5	autonomic ganglia	COSMIC	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation blocking phosphorylation signal	0.6111
p.V1128L	SIDM00337	Melanoma	GDSC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation altering degron motif	0.6765
p.L1480M	SIDM01218	Other Solid Cancers	GDSC	VKTSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.0556
p.G290W	SIDM00282	Colorectal Carcinoma	GDSC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation altering degron motif	0.6714
p.G290W	ACH-000998	Colon/Colorectal Cancer	CCLE	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation altering degron motif	0.6714
p.G290W	CW-2	large intestine	COSMIC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation altering degron motif	0.6714
p.I1036F	SIDM00865	Small Cell Lung Carcinoma	GDSC	DQETYSCKP	CBL_PTK	1043:1051	Mutation rewiring degron network	0.1389
p.I1036F	ACH-000530	Lung Cancer	CCLE	DQETYSCKP	CBL_PTK	1043:1051	Mutation rewiring degron network	0.1389
p.I1036F	DMS-114	lung	COSMIC	DQETYSCKP	CBL_PTK	1043:1051	Mutation rewiring degron network	0.1389
p.R1267H	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.0833
p.R1267H	ACH-000920	Leukemia	CCLE	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.0833
p.R1267H	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.0833
p.R1284W	SIDM00844	Burkitt's Lymphoma	GDSC	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.2222
p.R1284W	ACH-000654	Lymphoma	CCLE	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.2222
p.R1284W	Raji	haematopoietic and lymphoid tissue	COSMIC	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.2222
p.G567E	SIDM00814	Other Solid Cancers	GDSC	PLTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.3056
p.G567E	ACH-001401	Adrenal Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.3056
p.G567E	SW13	adrenal gland	COSMIC	PLTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.3056
p.K1136R	SIDM00537	Colorectal Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation substituting flanking lysine	0.3333
p.K1136R	ACH-001345	Colon/Colorectal Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation substituting flanking lysine	0.3333
p.K1136R	GP5d	large intestine	COSMIC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation substituting flanking lysine	0.3333
p.S1475F	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	VKTSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.1944
p.S1475F	ACH-000865	Esophageal Cancer	CCLE	VKTSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.1944
p.S1475F	KYSE-450	oesophagus	COSMIC	VKTSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.1944
p.E1472Q	SIDM00554	Ovarian Carcinoma	GDSC	VKTSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.2778
p.E1472Q	KURAMOCHI	ovary	COSMIC	VKTSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.2778
p.K653R	SIDM01618	B-Lymphoblastic Leukemia	GDSC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation substituting flanking lysine	0.3333
p.K653R	ACH-000942	Leukemia	CCLE	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation substituting flanking lysine	0.3333
p.S1165T	ACH-000139	Pancreatic Cancer	CCLE	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation blocking phosphorylation signal	0.6944
p.H569L	ACH-000774	Lung Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.25
p.R1169H	CML-T1	haematopoietic and lymphoid tissue	COSMIC	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation rewiring degron network	0.1389
p.K638N	CML-T1	haematopoietic and lymphoid tissue	COSMIC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.25
p.H1275N	ESS-1	endometrium	COSMIC	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.3056
p.S1136N	IMR-5	autonomic ganglia	COSMIC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation substituting flanking lysine	0.3333
p.I1168M	EN	endometrium	COSMIC	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation rewiring degron network	0.1667
p.M1119V	EW-18	bone	COSMIC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.0833
p.S1172N	IMR-5	autonomic ganglia	COSMIC	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation rewiring degron network	0.0556
p.V1128I	HOP-92	lung	COSMIC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation altering degron motif	0.7076
p.R656K	K2	skin	COSMIC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.1389
p.Q567E	U-698-M	haematopoietic and lymphoid tissue	COSMIC	PLTTS	DEG_SPOP_SBC_1	562:566	Mutation rewiring degron network	0.3056
p.E654Q	EPLC-272H	lung	COSMIC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation blocking phosphorylation signal	0.6389
p.Q651H	LCLC-103H	lung	COSMIC	RRRTLPQLP	DEG_APCC_DBOX_1	641:649	Mutation rewiring degron network	0.2778
p.I275T	JHH-4	liver	COSMIC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation rewiring degron network	0.0833
p.K1038N	SNU-175	large intestine	COSMIC	DQETYSCKP	CBL_PTK	1043:1051	Mutation rewiring degron network	0.1944
p.R1279W	NCI-H716	large intestine	COSMIC	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation altering degron motif	0.8634
p.K1038R	GP5d	large intestine	COSMIC	DQETYSCKP	CBL_PTK	1043:1051	Mutation rewiring degron network	0.1944
p.A288S	KYSE-70	oesophagus	COSMIC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation altering degron motif	0.7588
p.A288S	8305C	thyroid	COSMIC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	284:291	Mutation altering degron motif	0.7588
p.R1160H	DND-41	haematopoietic and lymphoid tissue	COSMIC	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation altering degron motif	0.8244
p.N1282D	MZ7-mel	skin	COSMIC	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.2778
p.L1170M	Daudi	haematopoietic and lymphoid tissue	COSMIC	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation blocking phosphorylation signal	0.5556
p.R1150W	Raji	haematopoietic and lymphoid tissue	COSMIC	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation rewiring degron network	0.2222
p.R1284M	GP5d	large intestine	COSMIC	PTSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.2222
p.L1159I	KURAMOCHI	ovary	COSMIC	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation altering degron motif	0.7174
p.A1128T	HOP-92	lung	COSMIC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation altering degron motif	0.7139
p.S1153F	NCI-H1568	lung	COSMIC	RRTRLGSLS	DEG_APCC_DBOX_1	1154:1162	Mutation rewiring degron network	0.3056
p.R1133H	CML-T1	haematopoietic and lymphoid tissue	COSMIC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation blocking phosphorylation signal	0.75
p.L1134M	Daudi	haematopoietic and lymphoid tissue	COSMIC	VSTTS	DEG_SPOP_SBC_1	1128:1132	Mutation rewiring degron network	0.2778
p.I1468T	JHH-4	liver	COSMIC	VKTSS	DEG_SPOP_SBC_1	1466:1470	Mutation altering degron motif	0.7078

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEP170

UniProt ID: Q5SW79

Entrez ID: 9859

Protein name: Centrosomal protein of 170 kDa (Cep170) (KARP-1-binding protein) (KARP1-binding protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEP170 in