DegronMD

Uniprot ID: Q5SW79

Source protein: Centrosomal protein of 170 kDa

Source gene: CEP170

Class: DEG_APCC_DBOX_1

Location: 1154:1162

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9922

ASA_SCORE: 104.6111

COIL: 0.9119

CONS_SCORE: 0.5861

DSS_SCORE: 0.5564

HELIX: 0.0524

FCONS_SCORE: 1.0728

RIG_SCORE: 0.6964

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1164C	TCGA-44-7662	LUAD	TCGA	RRTRLGSLS	DEG_APCC_DBOX_1	0.2778
p.Q1152R	TCGA-A6-2686	COAD	TCGA	RRTRLGSLS	DEG_APCC_DBOX_1	0.2778
p.Q1152E	TCGA-AC-A5XS	BRCA	TCGA	RRTRLGSLS	DEG_APCC_DBOX_1	0.2778
p.I1147V	TCGA-AO-A124	BRCA	TCGA	RRTRLGSLS	DEG_APCC_DBOX_1	0.1389
p.R1154L	TCGA-AP-A053	UCEC	TCGA	RRTRLGSLS	DEG_APCC_DBOX_1	0.7316
p.S1172Y	TCGA-AX-A05Z	UCEC	TCGA	RRTRLGSLS	DEG_APCC_DBOX_1	0.0556
p.S1172Y	TCGA-BS-A0UV	UCEC	TCGA	RRTRLGSLS	DEG_APCC_DBOX_1	0.0556
p.R1146W	TCGA-FI-A2D5	UCEC	TCGA	RRTRLGSLS	DEG_APCC_DBOX_1	0.1111
p.R1146W	ACH-000951	Lung Cancer	CCLE	RRTRLGSLS	DEG_APCC_DBOX_1	0.1111
p.R1146W	NCI-H2342	lung	COSMIC	RRTRLGSLS	DEG_APCC_DBOX_1	0.1111
p.S1165T	ACH-000139	Pancreatic Cancer	CCLE	RRTRLGSLS	DEG_APCC_DBOX_1	0.6944
p.R1169H	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	RRTRLGSLS	DEG_APCC_DBOX_1	0.1389
p.I1168M	EN	endometrium	COSMIC	RRTRLGSLS	DEG_APCC_DBOX_1	0.1667
p.S1172N	IMR-5	autonomic_ganglia	COSMIC	RRTRLGSLS	DEG_APCC_DBOX_1	0.0556
p.R1160H	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	RRTRLGSLS	DEG_APCC_DBOX_1	0.8244
p.L1170M	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	RRTRLGSLS	DEG_APCC_DBOX_1	0.5556
p.R1150W	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	RRTRLGSLS	DEG_APCC_DBOX_1	0.2222
p.L1159I	KURAMOCHI	ovary	COSMIC	RRTRLGSLS	DEG_APCC_DBOX_1	0.7174
p.S1153F	NCI-H1568	lung	COSMIC	RRTRLGSLS	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SW79	Centrosomal protein of 170 kDa	DEG_APCC_DBOX_1	1154:1162	RRTRLGSLS	APC,CDC20,FZR1	0.9922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons