DegronMD

Uniprot ID: Q5SW79

Source protein: Centrosomal protein of 170 kDa

Source gene: CEP170

Class: DEG_SCF_SKP2-CKS1_1

Location: 284:291

E3 ligase: SKP2,CSK1

DEGRON score: 0.8379

ASA_SCORE: 91.1

COIL: 0.923

CONS_SCORE: 0.6046

DSS_SCORE: 0.4554

HELIX: 0.0334

FCONS_SCORE: 0.9391

RIG_SCORE: 0.7074

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G276W	TCGA-05-4417	LUAD	TCGA	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.1111
p.G276W	DO23570	LUAD	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.1111
p.H297Y	TCGA-A5-A0G2	UCEC	TCGA	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.1667
p.H297Y	DO41235	UCEC	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P289T	TCGA-FS-A1ZN	SKCM	TCGA	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7031
p.P289T	DO38165	SKCM	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7031
p.P289S	TCGA-FW-A3R5	SKCM	TCGA	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.6752
p.P289S	DO37406	SKCM	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.6752
p.P289Q	DO225244	BRCA	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7035
p.R279T	DO44242	BRCA	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.1944
p.I275V	DO14250	HNSC	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.0833
p.F280L	DO218923	LUAD	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.2222
p.E286K	DO26520	LUSC	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7022
p.E286K	DO47727	STAD	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7022
p.P282L	DO220878	MELA	ICGC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.2778
p.F301V	SIDM02014	Esophageal Carcinoma	GDSC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.0556
p.G290W	SIDM00282	Colorectal Carcinoma	GDSC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.6714
p.G290W	ACH-000998	Colon/Colorectal Cancer	CCLE	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.6714
p.G290W	CW-2	large_intestine	COSMIC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.6714
p.I275T	JHH-4	liver	COSMIC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.0833
p.A288S	KYSE-70	oesophagus	COSMIC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7588
p.A288S	8305C	thyroid	COSMIC	FDDSTPGK	DEG_SCF_SKP2-CKS1_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SW79	Centrosomal protein of 170 kDa	DEG_SCF_SKP2-CKS1_1	284:291	FDDSTPGK	SKP2,CSK1	0.8379	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons