DegronMD

Uniprot ID: Q5SW79

Source protein: Centrosomal protein of 170 kDa

Source gene: CEP170

Class: DEG_SPOP_SBC_1

Location: 1128:1132

E3 ligase: SPOP

DEGRON score: 0.9947

ASA_SCORE: 95.62

COIL: 0.9508

CONS_SCORE: 0.4667

DSS_SCORE: 0.6592

HELIX: 0.025

FCONS_SCORE: 1.055

RIG_SCORE: 0.6151

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1133C	TCGA-4Z-AA7M	BLCA	TCGA	VSTTS	DEG_SPOP_SBC_1	0.75
p.S1133Y	TCGA-AP-A1DV	UCEC	TCGA	VSTTS	DEG_SPOP_SBC_1	0.75
p.S1133Y	TCGA-AX-A2HC	UCEC	TCGA	VSTTS	DEG_SPOP_SBC_1	0.75
p.R1133H	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.75
p.T1130A	TCGA-DU-6392	LGG	TCGA	VSTTS	DEG_SPOP_SBC_1	0.7139
p.A1128T	HOP-92	lung	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.7139
p.V1128I	HOP-92	lung	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.7076
p.V1128L	SIDM00337	Melanoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.6765
p.K1136N	SIDM00216	Colorectal Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.3333
p.K1136N	ACH-000989	Colon/Colorectal Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	0.3333
p.K1136N	SNU-175	large_intestine	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.3333
p.K1136R	SIDM00537	Colorectal Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.3333
p.K1136R	ACH-001345	Colon/Colorectal Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	0.3333
p.K1136R	GP5d	large_intestine	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.3333
p.S1136N	IMR-5	autonomic_ganglia	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.3333
p.A1126S	DO222849	COCA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.A1126S	DO228464	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.A1126S	DO231075	LUSC	ICGC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.A1126S	KU-19-19	urinary_tract	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.A1126S	NCI-SNU-5	stomach	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.A1126S	SNU-1040	large_intestine	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.A1126S	MRK-nu-1	breast	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.A1126S	SNU-C5	large_intestine	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.L1134M	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.T1120I	DO32576	OV	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1111

Showing 1 to 25 of 33 entries

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Drug responses associated with CEP170 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of VSTTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1128:1132	VSTTS	SPOP	0.9947	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	243:247	VSTTS	SPOP	0.9283	More...
Q99963	Endophilin-A3	DEG_SPOP_SBC_1	270:274	VSTTS	SPOP	0.9977	More...
P13647	Keratin, type II cytoskeletal 5	DEG_SPOP_SBC_1	578:582	VSTTS	SPOP	0.9568	More...
O95678	Keratin, type II cytoskeletal 75	DEG_SPOP_SBC_1	539:543	VSTTS	SPOP	0.9912	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12353:12357	VSTTS	SPOP	0.6523	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13758:13762	VSTTS	SPOP	0.7914	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1378:1382	VSTTS	SPOP	0.9643	More...
O95644	Nuclear factor of activated T-cells, cytoplasmic 1	DEG_SPOP_SBC_1	502:506	VSTTS	SPOP	0.7497	More...
P47736	Rap1 GTPase-activating protein 1	DEG_SPOP_SBC_1	617:621	VSTTS	SPOP	0.9852	More...
O75157	TSC22 domain family protein 2	DEG_SPOP_SBC_1	521:525	VSTTS	SPOP	0.9064	More...
Q9HCM3	UPF0606 protein KIAA1549	DEG_SPOP_SBC_1	883:887	VSTTS	SPOP	0.9959	More...

Showing 1 to 12 of 12 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSTTS

Degron related mutations and impact score

Drug responses associated with CEP170 mutations

All proteins holding degron of VSTTS