DegronMD - O75157(TSC22D2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A625S	TCGA-86-8358	LUAD	TCGA	LQLTPMNS	DEG_SCF_FBW7_1	628:635	Mutation rewiring degron network	0.25
p.A625S	DO25471	LUAD	ICGC	LQLTPMNS	DEG_SCF_FBW7_1	628:635	Mutation rewiring degron network	0.25
p.E213K	TCGA-91-6830	LUAD	TCGA	DSGLGAT	DEG_SCF_TRCP1_1	215:221	Mutation rewiring degron network	0.2778
p.E213K	DO25867	LUAD	ICGC	DSGLGAT	DEG_SCF_TRCP1_1	215:221	Mutation rewiring degron network	0.2778
p.S206I	TCGA-A5-A0G2	UCEC	TCGA	DSGLGAT	DEG_SCF_TRCP1_1	215:221	Mutation blocking phosphorylation signal	0.5278
p.S206I	DO41235	UCEC	ICGC	DSGLGAT	DEG_SCF_TRCP1_1	215:221	Mutation blocking phosphorylation signal	0.5278
p.N634S	TCGA-AX-A063	UCEC	TCGA	LQLTPMNS	DEG_SCF_FBW7_1	628:635	Mutation altering degron motif	0.5958
p.N634S	DO42201	UCEC	ICGC	LQLTPMNS	DEG_SCF_FBW7_1	628:635	Mutation altering degron motif	0.5958
p.A750T	TCGA-AX-A1CE	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.2778
p.A750T	TCGA-EY-A1GK	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.2778
p.A750T	DO42280	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.2778
p.A750T	DO42985	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.2778
p.V226A	TCGA-AX-A2HJ	UCEC	TCGA	DSGLGAT	DEG_SCF_TRCP1_1	215:221	Mutation rewiring degron network	0.1944
p.V226A	DO42105	UCEC	ICGC	DSGLGAT	DEG_SCF_TRCP1_1	215:221	Mutation rewiring degron network	0.1944
p.D215H	TCGA-CD-8529	STAD	TCGA	DSGLGAT	DEG_SCF_TRCP1_1	215:221	Mutation altering degron motif	0.7688
p.D215H	DO47753	STAD	ICGC	DSGLGAT	DEG_SCF_TRCP1_1	215:221	Mutation altering degron motif	0.7688
p.V513L	TCGA-CN-5360	HNSC	TCGA	VSTTS	DEG_SPOP_SBC_1	521:525	Mutation rewiring degron network	0.1111
p.V513L	DO14662	HNSC	ICGC	VSTTS	DEG_SPOP_SBC_1	521:525	Mutation rewiring degron network	0.1111
p.A760T	TCGA-EO-A22X	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.2222
p.A760T	DO43907	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.2222
p.A644S	TCGA-EO-A3KX	UCEC	TCGA	LQLTPMNS	DEG_SCF_FBW7_1	628:635	Mutation rewiring degron network	0.0833
p.A644S	DO219774	UCEC	ICGC	LQLTPMNS	DEG_SCF_FBW7_1	628:635	Mutation rewiring degron network	0.0833
p.S525F	TCGA-L5-A8NS	ESCA	TCGA	VSTTS	DEG_SPOP_SBC_1	521:525	Mutation altering degron motif	0.7982
p.P529S	TCGA-X2-A95T	SARC	TCGA	VSTTS	DEG_SPOP_SBC_1	521:525	Mutation rewiring degron network	0.2222
p.P529S	DO220309	SARC	ICGC	VSTTS	DEG_SPOP_SBC_1	521:525	Mutation rewiring degron network	0.2222
p.S525C	DO222937	BTCA	ICGC	VSTTS	DEG_SPOP_SBC_1	521:525	Mutation altering degron motif	0.7541
p.V518M	DO230309	COCA	ICGC	VSTTS	DEG_SPOP_SBC_1	521:525	Mutation rewiring degron network	0.25
p.Q758H	DO228952	LICA	ICGC	PGSTS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.2778
p.A512S	DO229025	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	521:525	Mutation rewiring degron network	0.0833
p.S205G	DO23178	LINC	ICGC	DSGLGAT	DEG_SCF_TRCP1_1	215:221	Mutation blocking phosphorylation signal	0.5
p.T207A	DO35242	PACA	ICGC	DSGLGAT	DEG_SCF_TRCP1_1	215:221	Mutation blocking phosphorylation signal	0.5556
p.V761M	SIDM00845	Burkitt's Lymphoma	GDSC	PGSTS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.1944
p.V761M	SIDM00461	Acute Myeloid Leukemia	GDSC	PGSTS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.1944
p.V761M	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PGSTS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.1944
p.V761M	ACH-000786	Lymphoma	CCLE	PGSTS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.1944
p.V761M	Daudi	haematopoietic and lymphoid tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.1944
p.V761M	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.1944
p.T527I	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	521:525	Mutation rewiring degron network	0.2778
p.P529A	SIDM01176	B-Lymphoblastic Leukemia	GDSC	VSTTS	DEG_SPOP_SBC_1	521:525	Mutation rewiring degron network	0.2222
p.P529A	ACH-000059	Leukemia	CCLE	VSTTS	DEG_SPOP_SBC_1	521:525	Mutation rewiring degron network	0.2222
p.P529A	SUP-B15	haematopoietic and lymphoid tissue	COSMIC	VSTTS	DEG_SPOP_SBC_1	521:525	Mutation rewiring degron network	0.2222
p.A750V	SIDM00997	Thyroid Gland Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.2778
p.A750V	ACH-001306	Thyroid Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.2778
p.A750V	8305C	thyroid	COSMIC	PGSTS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.2778
p.Q758K	SIDM00720	Mesothelioma	GDSC	PGSTS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.2778
p.S205N	SIDM01689	B-Lymphoblastic Leukemia	GDSC	DSGLGAT	DEG_SCF_TRCP1_1	215:221	Mutation blocking phosphorylation signal	0.5
p.S205N	ACH-000492	Leukemia	CCLE	DSGLGAT	DEG_SCF_TRCP1_1	215:221	Mutation blocking phosphorylation signal	0.5
p.N530D	ACH-001300	Neuroblastoma	CCLE	VSTTS	DEG_SPOP_SBC_1	521:525	Mutation rewiring degron network	0.1944
p.A621V	ACH-001843	Bile Duct Cancer	CCLE	LQLTPMNS	DEG_SCF_FBW7_1	628:635	Mutation rewiring degron network	0.1389
p.T747A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	752:756	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TSC22D2

UniProt ID: O75157

Entrez ID: 9819

Protein name: TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TSC22D2 in