DegronMD

Uniprot ID: O75157

Source protein: TSC22 domain family protein 2

Source gene: TSC22D2

Class: DEG_SPOP_SBC_1

Location: 521:525

E3 ligase: SPOP

DEGRON score: 0.9064

ASA_SCORE: 83.66

COIL: 0.922

CONS_SCORE: 0.3352

DSS_SCORE: 0.4567

HELIX: 0.0182

FCONS_SCORE: 0.8772

RIG_SCORE: 0.6774

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V513L	TCGA-CN-5360	HNSC	TCGA	VSTTS	DEG_SPOP_SBC_1	0.1111
p.V513L	DO14662	HNSC	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1111
p.S525F	TCGA-L5-A8NS	ESCA	TCGA	VSTTS	DEG_SPOP_SBC_1	0.7982
p.P529S	TCGA-X2-A95T	SARC	TCGA	VSTTS	DEG_SPOP_SBC_1	0.2222
p.P529S	DO220309	SARC	ICGC	VSTTS	DEG_SPOP_SBC_1	0.2222
p.S525C	DO222937	BTCA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.7541
p.V518M	DO230309	COCA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.25
p.A512S	DO229025	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.0833
p.T527I	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.P529A	SIDM01176	B-Lymphoblastic Leukemia	GDSC	VSTTS	DEG_SPOP_SBC_1	0.2222
p.P529A	ACH-000059	Leukemia	CCLE	VSTTS	DEG_SPOP_SBC_1	0.2222
p.P529A	SUP-B15	haematopoietic_and_lymphoid_tissue	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.2222
p.N530D	ACH-001300	Neuroblastoma	CCLE	VSTTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95644	Nuclear factor of activated T-cells, cytoplasmic 1	DEG_SPOP_SBC_1	502:506	VSTTS	SPOP	0.7497	More...
O95678	Keratin, type II cytoskeletal 75	DEG_SPOP_SBC_1	539:543	VSTTS	SPOP	0.9912	More...
P13647	Keratin, type II cytoskeletal 5	DEG_SPOP_SBC_1	578:582	VSTTS	SPOP	0.9568	More...
P47736	Rap1 GTPase-activating protein 1	DEG_SPOP_SBC_1	617:621	VSTTS	SPOP	0.9852	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1128:1132	VSTTS	SPOP	0.9947	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	243:247	VSTTS	SPOP	0.9283	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12353:12357	VSTTS	SPOP	0.6523	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13758:13762	VSTTS	SPOP	0.7914	More...
Q99963	Endophilin-A3	DEG_SPOP_SBC_1	270:274	VSTTS	SPOP	0.9977	More...
Q9HCM3	UPF0606 protein KIAA1549	DEG_SPOP_SBC_1	883:887	VSTTS	SPOP	0.9959	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1378:1382	VSTTS	SPOP	0.9643	More...
O75157	TSC22 domain family protein 2	DEG_SPOP_SBC_1	521:525	VSTTS	SPOP	0.9064	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons