DegronMD

Uniprot ID: Q9HCM3

Source protein: UPF0606 protein KIAA1549

Source gene: KIAA1549

Class: DEG_SPOP_SBC_1

Location: 883:887

E3 ligase: SPOP

DEGRON score: 0.9959

ASA_SCORE: 85.38

COIL: 0.9506

CONS_SCORE: 0.2518

DSS_SCORE: 0.6346

HELIX: 0.0134

FCONS_SCORE: 0.7173

RIG_SCORE: 0.7106

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T881A	TCGA-A2-A3Y0	BRCA	TCGA	VSTTS	DEG_SPOP_SBC_1	0.2778
p.T881A	DO44273	BRCA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.S887N	TCGA-DM-A1HB	COAD	TCGA	VSTTS	DEG_SPOP_SBC_1	0.7069
p.G889S	TCGA-HU-A4H8	STAD	TCGA	VSTTS	DEG_SPOP_SBC_1	0.2778
p.G889S	DO234278	ESAD	ICGC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.G889S	DO47869	STAD	ICGC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.G889S	ACH-000937	Leukemia	CCLE	VSTTS	DEG_SPOP_SBC_1	0.2778
p.G889C	TCGA-MP-A4TK	LUAD	TCGA	VSTTS	DEG_SPOP_SBC_1	0.2778
p.G889C	DO45384	LUAD	ICGC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.E882K	TCGA-QC-A7B5	SARC	TCGA	VSTTS	DEG_SPOP_SBC_1	0.3056
p.E882K	DO220239	SARC	ICGC	VSTTS	DEG_SPOP_SBC_1	0.3056
p.G889V	DO229010	COCA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.G889V	DO229003	COCA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.P876T	DO229028	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1389
p.A891T	DO224767	PACA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.2222
p.T885I	SIDM00779	Colorectal Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.7078
p.T885I	ACH-000491	Colon/Colorectal Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	0.7078
p.T881M	SIDM01033	Bladder Carcinoma	GDSC	VSTTS	DEG_SPOP_SBC_1	0.2778
p.T886P	ACH-002093	Bone Cancer	CCLE	VSTTS	DEG_SPOP_SBC_1	0.7031
p.T886P	CHSA0108	bone	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95644	Nuclear factor of activated T-cells, cytoplasmic 1	DEG_SPOP_SBC_1	502:506	VSTTS	SPOP	0.7497	More...
O95678	Keratin, type II cytoskeletal 75	DEG_SPOP_SBC_1	539:543	VSTTS	SPOP	0.9912	More...
P13647	Keratin, type II cytoskeletal 5	DEG_SPOP_SBC_1	578:582	VSTTS	SPOP	0.9568	More...
P47736	Rap1 GTPase-activating protein 1	DEG_SPOP_SBC_1	617:621	VSTTS	SPOP	0.9852	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1128:1132	VSTTS	SPOP	0.9947	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	243:247	VSTTS	SPOP	0.9283	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12353:12357	VSTTS	SPOP	0.6523	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13758:13762	VSTTS	SPOP	0.7914	More...
Q99963	Endophilin-A3	DEG_SPOP_SBC_1	270:274	VSTTS	SPOP	0.9977	More...
Q9HCM3	UPF0606 protein KIAA1549	DEG_SPOP_SBC_1	883:887	VSTTS	SPOP	0.9959	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1378:1382	VSTTS	SPOP	0.9643	More...
O75157	TSC22 domain family protein 2	DEG_SPOP_SBC_1	521:525	VSTTS	SPOP	0.9064	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons