DegronMD

Uniprot ID: O95678

Source protein: Keratin, type II cytoskeletal 75

Source gene: KRT75

Class: DEG_SPOP_SBC_1

Location: 539:543

E3 ligase: SPOP

DEGRON score: 0.9912

ASA_SCORE: 86.44

COIL: 0.8842

CONS_SCORE: 0.809

DSS_SCORE: 0.4518

HELIX: 0.0168

FCONS_SCORE: 1.0294

RIG_SCORE: 0.7

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S548R	TCGA-A5-A0G2	UCEC	TCGA	VSTTS	DEG_SPOP_SBC_1	0.1944
p.S548R	DO41235	UCEC	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1944
p.T550K	TCGA-VQ-A8PH	STAD	TCGA	VSTTS	DEG_SPOP_SBC_1	0.1389
p.T550K	DO222349	STAD	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1389
p.H551Q	DO228976	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1111
p.T550M	DO229050	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1389
p.T550M	DO228179	PBCA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1389
p.T550M	SNU-175	large_intestine	COSMIC	VSTTS	DEG_SPOP_SBC_1	0.1389
p.Y549H	DO50872	LICA	ICGC	VSTTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95644	Nuclear factor of activated T-cells, cytoplasmic 1	DEG_SPOP_SBC_1	502:506	VSTTS	SPOP	0.7497	More...
O95678	Keratin, type II cytoskeletal 75	DEG_SPOP_SBC_1	539:543	VSTTS	SPOP	0.9912	More...
P13647	Keratin, type II cytoskeletal 5	DEG_SPOP_SBC_1	578:582	VSTTS	SPOP	0.9568	More...
P47736	Rap1 GTPase-activating protein 1	DEG_SPOP_SBC_1	617:621	VSTTS	SPOP	0.9852	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	1128:1132	VSTTS	SPOP	0.9947	More...
Q8WWK9	Cytoskeleton-associated protein 2	DEG_SPOP_SBC_1	243:247	VSTTS	SPOP	0.9283	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12353:12357	VSTTS	SPOP	0.6523	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	13758:13762	VSTTS	SPOP	0.7914	More...
Q99963	Endophilin-A3	DEG_SPOP_SBC_1	270:274	VSTTS	SPOP	0.9977	More...
Q9HCM3	UPF0606 protein KIAA1549	DEG_SPOP_SBC_1	883:887	VSTTS	SPOP	0.9959	More...
E2RYF6	Mucin-22	DEG_SPOP_SBC_1	1378:1382	VSTTS	SPOP	0.9643	More...
O75157	TSC22 domain family protein 2	DEG_SPOP_SBC_1	521:525	VSTTS	SPOP	0.9064	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons